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New Member

Date Joined Jan 2012
Total Posts : 13
   Posted 1/28/2012 7:00 AM (GMT -6)   
Hi All! I was so happy to come across this site, I felt so alone after my diagnosis as I don't know anyone else with connective tissue disease. I have recently been diagnosed with Undiff. connective tissue disease with symptoms most like lupus per my rheum (muscle aches, dry eyes, dry mouth, leukopaenia, arm rashes, and major insomnia). The only test results to come back positive after my rheum consult were an ANA (1:1260) and a positive anti RNP (6.0). I began treatment on generic Plaquenil 200 mg. the first week and then 400 mg. for the last 2 1/2 weeks. I also began Restasis to help with the eye issues.

Unfortunately, I developed a rash on my face (near mouth) and on neck and the rheum advised me to discontinue the generic Plaquenil for a week and then re-introduce at 200 mg. to see what happens. I was heart broken, this medication was like a wonder drug for me - it was the best I felt in months.

Has anyone had this issue and been able to successfully re-introduce themselves to Plaquenil? I have seen some posts about generic vs. name-brand differences and different anti-malarial drugs but the amount of information is so overwhelming and I am doing good just dealing with the fact of having an autoimmune disease.....

Thank you!


Regular Member

Date Joined Jan 2006
Total Posts : 395
   Posted 1/28/2012 10:00 AM (GMT -6)   
Miracle drug for me, too. Maybe it would be worth the $$$ increase to try the brand name?
hugs, welcome and keep us posted
God knows, even if I don't....
CNS Lupus 2005, APS, Hashimoto's Thyroiditis, Degenerative Osteoarthritis, Asthma
Meds: Plaquenil, Neurontin, Thyroid, meloxicam, Aspirin, Atenolol and Norvasc, Prednisone 5mg daily. (20-40mg prn), Vit. B12 2400 mcgs, Vit D 1000U, Calcium, Flector patch prn, Ambien and Elavil every night. Advair, Albuterol and DuoNeb inhalers.

Veteran Member

Date Joined May 2005
Total Posts : 7723
   Posted 1/28/2012 10:16 AM (GMT -6)   
The first time I used the generic I had a rash reaction, although not as extreme as what you are having. That was in 2002. I've been on the brand Plaquenil since then with great results.

And then last month they accidentally sent me the generic and I've been taking it with no problems this time.

SO I'd say give it another try like the dr suggests -- if that doesn't work then try the brand name. Also note that there are a couple of brands of generic plaquenil, so possibly if you ask at another pharmacy they may have a different generic that might work better!
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 1/28/2012 11:00 AM (GMT -6)   
The restasis was bad for me. My face swelled up, eyelids turned bruised-looking, and I itched.
Has your doctor considered this as your allergen?

New Member

Date Joined Jan 2012
Total Posts : 13
   Posted 1/28/2012 4:41 PM (GMT -6)   
Thank you for the info - you guys are great! I have been off the Plaquenil for a day and the rash has greatly improved. Hopefully restarting on the lower dose next week will not cause the rash to reappear...if so, I will discuss prescribing the name brand with my rheum. Keeping my fingers crossed that there is enough Plaquenil in my system to keep my pain level in check until I can restart :-)

New Member

Date Joined Jan 2012
Total Posts : 13
   Posted 2/20/2012 7:33 PM (GMT -6)   
A million thanks Lynnwood for the tip!!!!! I restarted on 200 mg of the generic Plaquenil with only a minor rash and quite a bit of itching (which I was ready to deal with as the medication made me feel so much better). I went back to the rheum last week and discussed the brand name medication and he was happy to write the script because he wanted me back on 400 mg asap. I have been back on it a week and now have absolutely no itching and no rashes.
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