Currently, I am tapering off the Prednisone to get ready for the Rituxan. I am down to 10mg one day and 0mg the next. Each time I lower the Prednisone, my body, which LOVES Prednisone, goes through some unhappy times. Thankfully, it doesn't last long. My Rheumy and I are just waiting to hear back from the insurance company to get the green light to proceed with the Rituxan. I met one woman who has had remarkable luck with this drug. I had misgivings at first because of all the possible side effects, but realized that all medicines have their good and not so good aspects. Thanks for your thoughts!