After much thought and deliberation I have decided to follow through with the Rituxan therapy that my doctor is proposing. I have gotten so Prednisone dependent that I can't seem to function without it. Every time we get down to 5 mg., my symptoms come roaring back full force. I have been developing side effects to the medication-weakened bones, heavy bruising, stomach problems-that sometimes comes with long time steroid use, so my decision to try something else was relatively easy to make. I have exhausted all of the other possibilties. Cell cept had been a god-send, but I experienced severe bone marrow suppression from it. I can't take NSAIDs and Methotrexate made me quite ill. My body loves Prednisone and I have done quite well with it. Too bad it has such horrid side effects with long term use. I am waiting to hear back from my insurance company and we will go from there. I have to admit that I am a little leery of this new medication, but after researching it and getting a second opinion, I thought it was the best way for me to go. I want to keep feeling well and not getting so sick all of the time. Any thoughts from any other forum members would be greatly appreciated!!