My doctors have not mentioned either of them to me yet, and I have not yet researched them. Every medicine, prescription or over the counter, has side effects. That makes it so hard knowing which ones are the least dangerous and whether the pain relief is worth the risk. Plus, meds effect each person differently. Many times over the years, I've opted for the pain relief over the possible risks in order to be able to function in life. I'll do some research on those two you mentioned, then discuss them with my Dr when I go for follow-up lab work and exam later this month. Thanks!