I started Imuran yesterday. One pill for one week and then I go to two pills the following week. I felt pretty sick to my stomach yesterday and had some intestinal discomfort, with some lethargy by the end of the day. Had some of the same sensations this morning when I woke up, but by the end of the day I felt like my old self. Is this normal with this medication? When I tried Methotrexate, I started out really sick and it continued with a vengence until I stopped taking the drug a week later. I have been reading quite a bit on Imuran and the side effects run the gamut depending on the individual. Anything I should be looking out for?? I really want this medication to work so I can start being weaned off the Prednisone. Any insights would be appreciated!