Hello, I am new here, looking for some help in understanding how lab work is used in diagnosis of lupus. I have gotten two positive ANA tests, first was 1:640 homogenous, second was 1:256... since gotten a negative test, after being referred to rheumy. Rheumy said I should be reassured that I don't have lupus. However, my lab results that he ordered also showed I have sky-high levels of anti-chromatin (336, when normal range was 0-99). I also have high anticentromere results and high Anti-ssDNA results. After doing a lot of research specifically on the anti-chromatin levels, I am as confused as ever.
I am wondering specifically whether any of you have gotten positive ANAs, then negative ones, and still have a lupus diagnosis. Also, have any of you gotten a diagnosis based on high anti-chromatin levels alone?
From what I have read, anti-chromatin antibodies are an early sign of lupus nephritis development.
Thank you for reading and for any advice.