anti-chromatin levels elevated=lupus? or nothing to worry about?

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mainemommy
New Member


Date Joined Jun 2012
Total Posts : 3
   Posted 6/3/2012 5:08 AM (GMT -6)   
Hello, I am new here, looking for some help in understanding how lab work is used in diagnosis of lupus. I have gotten two positive ANA tests, first was 1:640 homogenous, second was 1:256... since gotten a negative test, after being referred to rheumy. Rheumy said I should be reassured that I don't have lupus. However, my lab results that he ordered also showed I have sky-high levels of anti-chromatin (336, when normal range was 0-99). I also have high anticentromere results and high Anti-ssDNA results. After doing a lot of research specifically on the anti-chromatin levels, I am as confused as ever.

I am wondering specifically whether any of you have gotten positive ANAs, then negative ones, and still have a lupus diagnosis. Also, have any of you gotten a diagnosis based on high anti-chromatin levels alone?

From what I have read, anti-chromatin antibodies are an early sign of lupus nephritis development.

Thank you for reading and for any advice.

couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14475
   Posted 6/4/2012 9:52 AM (GMT -6)   
I've heard others here talk about their ANA levels changing. I would think with two positive ANA tests you would be deemed positive with lupus or other related autoimmune problem.

I'd think I'd find a different Rhuemy. One who's not so wishy-washy.
Joy

mainemommy
New Member


Date Joined Jun 2012
Total Posts : 3
   Posted 6/6/2012 8:49 AM (GMT -6)   
Thank you Joy. I am attempting to get in with another rheumy for a second opinion, however there are only a couple in my area in Maine and they're booking out to December. Meanwhile, my primary won't give much advice and my endocrinologist (who I see for hashimoto's thyroiditis) did inform me that the positive ANA could not possibly be from my thyroid disease.

The more I read about chromatin antibodies, the more I think I will be diagnosed with SLE or perhaps autoimmune hepatitis.

couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14475
   Posted 6/6/2012 11:22 AM (GMT -6)   
You have hashimoto's? My doctor thinks I had it and my thyroid has now settled down to hypothyroid state.

Our bodies are a fickle thing aren't they?
Joy

mainemommy
New Member


Date Joined Jun 2012
Total Posts : 3
   Posted 6/6/2012 11:43 AM (GMT -6)   
Yes, seems so. I've gone into hyperthyroid twice in the past few years, but am primarily hypothyroid. I've been on thyroid meds for almost 20 years now.
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