I've tried MANY things over the years at one point or another- ambien, lunesta, benzos, benadryl, magnesium, etc. I was sleeping like a rock after being diagnosed (except when on high-dose steroids at first), until going on plaquenil. I started taking Melatonin. 5mg didn't do anything for me, but 10 works great. I take it at least an hour before bed, and I don't get a drowsy feeling from it and I certainly don't feel groggy the next morning. Definitely ask your Dr, obviously, as I know it may stimuluate the immune system- and could instigate a flare. I have never had any problems, and I've been taking it for about six months. Good luck!