What causes Lupus?

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Triple L
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Date Joined Jul 2012
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   Posted 7/14/2012 9:58 PM (GMT -6)   
I am new to this forum so, please forgive me if this question has already been explored. I am a long suffering Lupus patient and have never been satisfied with the answers or lack of answers to this question. So, can anyone share some insight? How did we get here?
Is our condition hereditary.
Environmentally based?
Stress induced?
The product of some untreated infection?
Any thoughts?

Little Rosie
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Date Joined Jul 2012
Total Posts : 3
   Posted 7/15/2012 9:14 AM (GMT -6)   
You sound as bewildered as I feel.........
Sry I don't have the reply for you, that you want. Hopefully someone will along and answer and I can learn also......

Lynnwood
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Date Joined May 2005
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   Posted 7/15/2012 9:30 AM (GMT -6)   
All of those reasons and others have been suggested, and many believe them. The truth is that as of now, there is no scientifically or medically documented and verified reason or process that shows what might cause Lupus.

The one exception to that are the cases of medically induced Lupus, where certain drugs are cited as the cause -- these are in the minority.
Lynnwood, Lupus & Sjogren's Moderator
DIAGNOSING-LUPUS & LUPUS-RESOURCES
"Life is far too important to be taken seriously" - Oscar Wilde

Bsime
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Date Joined Apr 2006
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   Posted 7/15/2012 8:54 PM (GMT -6)   
The cause of lupus is not known.  It is believed there is a genetic connection, but lupus is not a genetic disease.  In other words, you might have a set of genes that predisposes your immune system to a disruption or misdirection.  That trigger could be any number of different things but nobody has been able to prove what causes lupus.  Many patients will claim they know what caused their lupus but that is entirely conjecture on their part.
 
Here is the LFA commentary on the subject.
 
 
Bill

Triple L
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Date Joined Jul 2012
Total Posts : 8
   Posted 7/15/2012 9:33 PM (GMT -6)   
The week of my first symptom I was taking penicillin following the extraction of my wisdom teeth. I had the medication before but this time on the third day my skin erupted with hives that eventually became blisters. Following ER treatment with solumedrol and benadryl I was placed on a high dose of Prednisone. My odyssey began here or so it seems. It's kinda funny that when I reflect on my illness I have more angst about how and why than the actual challenges. I can have the faith that I can get through what I'm going through but I can't shake the frustration that comes with not knowing why. I find consolation of sorts in the words of Dr. Viktor Frankl which are "He who has a why to live for can bear with almost any how." He survived a lengthy imprisonment in Aushwitz. I don't think that I will ever be satisfied with the wall of not knowing but I will continue to live through it because like everyone here I've got plenty of reasons. Take good care, L.

LAWCHICK
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Date Joined Jul 2010
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   Posted 7/17/2012 9:53 AM (GMT -6)   
That seems to be the million dollar question. It can be genetic I think. Also I read an article about certain blood infections leading to lupus such as strep. Its interesting because I had a strep blood infection as a child. Makes ya wonder!

Bsime
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Date Joined Apr 2006
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   Posted 7/17/2012 11:56 AM (GMT -6)   
I think researchers will ultimately find there are many paths (triggers) to lupus. Not just one. Most of them will also involve genes but not like a true genetic disease where if you have the mutation, you are 100% certain to get the disease. Genes set up a precondition and then the right trigger(s) is needed to cause the disease. Once they understand the mechanism on a cellular basis they can work backword to what gene mutation might be causing the disease. It is easier to do it in hereditary diseases because you can focus on the mutation within a family to see what is different.

Bill
MCTD (SLE Lupus, polymyositis, scleroderma). Diagnosed 2005. Kidney, liver, GI tract, dysphagia, raynauds, barretts esophagus, quadriplegic in 2005. Recovered and now active in downhill skiing, golf, hiking. Meds: amlodipine, benezapril, omeprazole, potassium, folic acid, vitamins, maxide.

Remain Optimistic and you can overcome.

combs
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Date Joined Jul 2012
Total Posts : 2
   Posted 7/25/2012 8:45 PM (GMT -6)   
I have a friend w/ Lupus and have been researching. Since digestive problems seem to be at the heart of mant symptoms and we know that these are usually caused by an overgrowth of Candida Albicans and Pau D Arco is used in Soth America as a treatment for Lupus and it is MAJOR candida killer- could an overgrowth of yeast in the body from antibiotics and steroids be at the root?

Bsime
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Date Joined Apr 2006
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   Posted 7/25/2012 9:13 PM (GMT -6)   
Not likely.  Candida is in our bodies and when you take suppression meds it can become a problem...particularly with steroids.  Some lupers have digestive problems but not everybody.  The relationship has never been proven but there are doctors who push unproven meds and alternative treatments.
 
If it was that easy, researchers would have found it long ago and come up with a way to control candida.
 
The most likely explanation is that we inherit a set of genes that predispose our immune system to a disruption by something....chemical, virus, bacteria, who knows.  It is a complex mechanism and that is why it is so difficult to understand.  new avenues of genetic research will eventually open the door by exposing what is deficient in the genome of lupers and others with AI diseases.  once that is understood, treatments can be devised.  Right now nobody understands the mechanisms and some are just throwing darts.....sometimes just to make money on treatments that don't work.
 
Bill
MCTD (SLE Lupus, polymyositis, scleroderma). Diagnosed 2005. Kidney, liver, GI tract, dysphagia, raynauds, barretts esophagus, quadriplegic in 2005. Recovered and now active in downhill skiing, golf, hiking. Meds: amlodipine, benezapril, omeprazole, potassium, folic acid, vitamins, maxide.

Remain Optimistic and you can overcome.

combs
New Member


Date Joined Jul 2012
Total Posts : 2
   Posted 7/26/2012 6:39 AM (GMT -6)   
Thanks BSIME
Yes, I agree that there is a genetic predisposition to Lupus, but could it not be activated by a virus

Bsime
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Date Joined Apr 2006
Total Posts : 1342
   Posted 7/26/2012 8:06 AM (GMT -6)   
Possible. More likely that is it some other environmental exposure that might happen over a period of years rather than just a single event.
 
Bill

couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14475
   Posted 7/26/2012 9:42 AM (GMT -6)   
IMHO I believe the genetic predisposition is sitting there like a time bomb and something happens to trigger it. If we could find out the trigger maybe we stop the "explosion".
Joy

NanaBee
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Date Joined Jun 2005
Total Posts : 541
   Posted 7/26/2012 6:15 PM (GMT -6)   
For what it is worth as far as genetics go - my mom had Type1 Diabetes, I have MCTD, and my sister has Hashimoto's disease. I believe all three are autoimmune. Each one of us just manifested with a different disease.

However, none of my children or grandchildren have any autoimmune disorders.

That's my two cents from experience.

Mary Ann
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