confused over differing ANA patterns, can you have both?

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New Member

Date Joined Jul 2012
Total Posts : 9
   Posted 10/2/2012 3:59 PM (GMT -6)   
I've been bopping around to and through forums for the last 3 months as I await the answers that will tell us what the heck is going on with me.
A brief (abridged) version of my "stuff:"
1.  20+ years raynauds
2.  20+ years ibs
3.  Recent (3 months ago) pain like mad in my shins/calves and sometimes in my arms from elbows down. Achy radiant pain in arms...fatigue and sharp pain in my legs.
4.  Ana 1:640 centromere pattern
5.  Morphea and lichen sclerosis.
fast forward 3 months to now
all of the above but...
ANA 1:1280 with speckled pattern.
Can you have both?  What in the world would something like that mean?
My rheumy is going to run more 'defining' blood tests and go over my history in more detail with me...I'm just worried and confused.

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 10/2/2012 4:46 PM (GMT -6)   
If I understand right, patterns can change.

Speckled pattern usually goes with SLE.

You might have MCTD???

I'd wait for the doctor's answer before I start jumping to conclusions though.
Lupus, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, Degenerative Disk and Facet Disease, and Allergies

When life throws you lemons....
Pick them up and throw them right back at them! :))

Veteran Member

Date Joined May 2005
Total Posts : 7723
   Posted 10/2/2012 6:10 PM (GMT -6)   
centromere pattern is most often associated with CREST (Calcinosis; Raynaud's; Esophageal dysmotility; Sclerodactyly; Telangectasias)

The speckled pattern is found in SLE and other connective tissue diseases.

I have read both that the pattern can change and that you can have 2 patterns at once (although 2 at once confuses me!).

It is also important to remember that an ANA does NOT define the disease! It may suggest a disease to look for, and *if* other symptoms of that disease are found then, and only then, would it be diagnosed.

A positive ANA alone may not mean anything! Strange, huh? More on ANA is found in our thread Lupus Resources (link below).

Try not to worry too much, worry/stress can make these diseases more symptomatic, and not worrying can certainly not hurt you. Just carry on following up...

Best wishes,
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde
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