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Regular Member

Date Joined Aug 2011
Total Posts : 74
   Posted 10/6/2012 2:56 PM (GMT -6)   
I have had lupus for many years (almost 10) and the only test that came back for lupus, other than the ANA was the antiSM. Anyway, I just had some blood work done and now they found that I have anti dsDNA and I am not sure what this means. Is it significant? I have so much going wrong with my body lately that I am a little overwhelmed. I know that all my kidney tests and liver tests came back normal so I am not really worried about that right now. Just wondering why I would have that come back positive when it never did before.

Thanks for reading and for any answers.


Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 10/7/2012 9:08 PM (GMT -6)   

The anti-dsDNA test may be used to monitor disease activity in a person who has been diagnosed with SLE. Those with SLE often have flare-ups where symptoms worsen and then die down. Increased anti-dsDNA levels may be seen prior to and during these flare-ups.

A very low level of anti-dsDNA is considered negative but does not exclude a diagnosis of SLE. Only about 50-60% of those with SLE will have anti-dsDNA. Low to moderate levels of the autoantibody may be seen with other autoimmune disorders, such as Sjögren syndrome and mixed connective tissue disease (MCTD).

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