Some people get an upset stomach for a few days until they get used to the Plaquenil, but I have never heard of symptoms like you are describing.
It might be Plaquenil or it might be the water pill. I suggest stopping one or the other and see if symptoms improve. I would probably stop the water pill first, as I think it's more likely to give yo these symptoms and it gets out of your system faster. But stopping either would work.
Sadly, sometimes we just have to experiment a little. Hope this helps.
Lynnwood, Lupus & Sjogren's ModeratorDIAGNOSING LUPUS & LUPUS RESOURCES
"Life is far too important to be taken seriously" - Oscar Wilde