Negative ana with positive DS DNA?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Megan Eliz
Regular Member

Date Joined Apr 2013
Total Posts : 65
   Posted 7/2/2013 2:58 PM (GMT -6)   
My 5 year old daughter has been having on and off aches and pains.  She is being seen by a rheumatologist.  In April she had a positive ANA (1:160) and an equivocal anti dsdna.
They redid the tests 2 months later and now her ANA is negative but her Anti-dsdna is now positive at 1.18 (positive is above 1.10).  Her RNP/Smith ABS was negative as was her Smith Igb.
Was wondering what this could mean while I wait for her doc to call me back.  I thought for sure her ANA would be positive if her anti dsdna is also positive.  How can one be negative and one positive?
Just curious if anyone has experience with this.  She seems fine now.  Random pains here and there but nothing where I would be too concerned.
Of course now I am freaking out (okay trying to stay calm)

Post Edited (Megan Eliz) : 7/2/2013 2:01:03 PM (GMT-6)

Veteran Member

Date Joined May 2005
Total Posts : 7723
   Posted 7/2/2013 3:50 PM (GMT -6)   
Okay, stay calm. All you can do right now is the next right thing to distract yourself from worry.

The most important thing is that your daughter is feeling fine now. Many of the auto-immune diseases are diagnosed by actual symptoms, blood tests don't tell us much about the total picture. For instance, check out the 4 of 11 link in my signature.

Keep breathing.
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

Megan Eliz
Regular Member

Date Joined Apr 2013
Total Posts : 65
   Posted 7/2/2013 4:43 PM (GMT -6)   
Thanks.  I am trying to just relax.
I guess my confusion is how can a test for ANA be negative but she has a positive anti ds dna test. I thought anti ds dna antibodies would make the ana positive 
Spoke to the doc who said she was just as confused and that the results do not make sense.  Basically said it was probably a false positive.  We are done with the rheumatologist for now unless a problem crops up.
I know I should feel better but I am just trying to process everything.  I keep thinking what if the doc is wrong and something is wrong.  I am trying to just be happy but I keep thinking this test must mean something.  I wish we never had to have any of these tests at all.

Post Edited (Megan Eliz) : 7/2/2013 4:57:13 PM (GMT-6)

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 7/2/2013 7:49 PM (GMT -6)   
I would just try not to worry unless she starts showing symptoms. There are some people who have positive ANA and other antibodies but never develop symptoms. Let's pray it doesn't develop.

My 21 yr old niece had a positive RNP on her bloodwork 3 years ago but has not show any other signs.
Lupus, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, OA, Depression, and Allergies

When life throws you lemons....
Pick them up and throw them right back at them! :))
New Topic Post Reply Printable Version
Forum Information
Currently it is Sunday, September 23, 2018 8:44 PM (GMT -6)
There are a total of 3,005,942 posts in 329,287 threads.
View Active Threads

Who's Online
This forum has 161811 registered members. Please welcome our newest member, Clifton Winstead.
284 Guest(s), 10 Registered Member(s) are currently online.  Details
Youngguy90, SoMuchFun, logoslidat, HeartsinPain, mattamx, Spring, pombear, JOKERWILD477, Anitas, Clifton Winstead