Your blood work suggests mctd....ana, speckled pattern and anti rnp antibody. MCTD is a disease with a 1000 faces and can present differently in every case. There is no standard pattern. Mine presented with lupus/arthritic type symptoms and attacked my kidneys. Also general feeling of malaise/fatigue and soon weakness. Within a short time it had attacked every joint, kidneys, GI track, and muscles (with lots of muscle pain).
Plaquinel is usually not effective if you have mctd and prednisone and some other med like Imuran or methotrexate at the same time. As those kick in prednisone is reduced and hopefully your immune system will be controlled.
Also had "lupus fog."
If you are not confident of your diagnosis or treatment get a second opinion. MCTD or lupus alone are not easy diseases to treat and you should see an experienced rheumy.
MCTD (SLE Lupus, polymyositis, scleroderma). Diagnosed 2005. Kidney, liver, GI tract, dysphagia, raynauds, barretts esophagus, quadriplegic in 2005. Recovered and now active in downhill skiing, golf, hiking. Meds: amlodipine, benezapril, omeprazole, potassium, folic acid, vitamins, maxide.
Remain Optimistic and you can overcome.