Sulfasalazine - Anti-inflammatory?

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Regular Member

Date Joined Jul 2012
Total Posts : 73
   Posted Today 8:52 PM (GMT -6)   
Has anyone tried Sulfasalazine as an anti-inflammatory? So far so good! My joints have not hurt but then again when I start on something new it almost always starts off well....Here's hoping it stays working. wink

Post Edited By Moderator (Lynnwood) : 9/23/2013 5:38:57 AM (GMT-6)

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted Today 9:07 PM (GMT -6)   
I've never heard of it before. Does it contain sulfur? I have an allergy to sulfur drugs?
Lupus, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, OA, Depression, and Allergies

When life throws you lemons....
Pick them up and throw them right back at them! :))

Barbara Lee
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Date Joined Sep 2003
Total Posts : 2889
   Posted 9/23/2013 12:21 AM (GMT -6)   
I've never heard of this drug either. I'll have to look it up, how are you doing on it. Is it an overall generally make you feel better type of drug? Or does it set it's eye's on a specific symptom and attacks it?

Hope you continue to feel better. Please keep up posted on how you're doing.

DX- RA, Lupus, Fibro, LGL Leukemia, Pulmonary Hypertension, Bells Palsy, Gastroparsis, Blood Clots, Glaucoma, Chronic Pericarditis & Pleurisy, Severe Anemia. Way to many medications to list.

Veteran Member

Date Joined May 2005
Total Posts : 7723
   Posted 9/23/2013 6:38 AM (GMT -6)   
I've heard of Sulfasalazine before -- I think it's usually used to treat RA. I am also allergic to sulfa-based medications, and yes, Sulfasalazine is sulfa based. The literature says that most Lupus patients have a sulfa allergy.

For me, I got a thin rash of little pink spots all over my body...just didn't want to wait till it got worse. I understand some people have more severe reactions.
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

Forum Moderator

Date Joined Apr 2005
Total Posts : 17895
   Posted 9/24/2013 9:14 AM (GMT -6)   
I used it for 11 years for the inflammation of Crohn's disease and it worked very well for me.  They also use it for ankylosing spondylitis...and inflammatory disease of the spine.  It's a good drug.  Yes, it's a sulfa drug.  The brand name is Azulfadine.
Forum Moderator/Fibromyalgia

Fibromyalgia, Crohn's Disease, Ostomy, Autoimmune Inner Ear Disease, Diabetes, Osteoporosis, Glaucoma, Scoliosis, Ankylosing Spondylitis
God does not give us a spirit of fear, but of power and of love and of a sound mind. 2 Timothy 1:7

Regular Member

Date Joined Jul 2012
Total Posts : 73
   Posted 9/28/2013 5:33 PM (GMT -6)   
Well it was nice to feel normal for a week or so. I had and still am having a very bad flare! Me legs are on fire!! They hurt so bad and I'm super depressed because I was hoping this would be the one drug that would make me feel normal again! I hate hate hate feeling pain again...sorry that it didn't work for me or us.

I know I press on but for now I'm choosing to be angry and depressed! I hate Lupus!!!!! I don't know how some of u have had it for years and do you cope with the pain and all the other things that come with it? My goodness!!!

Luv you all...God bless

Veteran Member

Date Joined Sep 2005
Total Posts : 1744
   Posted 10/1/2013 8:46 AM (GMT -6)   
I've taken sulfasalazine before for RA.  One of the drugs I had to "fail" before moving on to the biologics.  Sulfasalazine, as someone already pointed out, commonly causes allergic reactions in certain populations.  After about 4-5 weeks on the drug, my blood counts plummeted and I developed petichiae (sp) all over my body.  It was only the prednisone I received from an ER doctor that brought my platelets back up to normal.  After that scary experience, I stopped sulfasalazine and was told that I was allergic to sulfa drugs (even though I never was before). 
If you are not allergic to sulfasalazine, however, I've heard it can be a very good drug.

Regular Member

Date Joined Feb 2011
Total Posts : 399
   Posted 10/1/2013 8:25 PM (GMT -6)   
I took it for severe inflammation in both my small and large intestine.  It worked for a while, but then I had to stop because I had a reaction to it.  They switched my to high doses of Prednisone, which ultimately cleared up the inflammation.

Regular Member

Date Joined Jul 2012
Total Posts : 73
   Posted 12/31/2013 11:34 AM (GMT -6)   
oreo...aren't you afraid of the high doses of Prednisone? my rheumy won't put me back on all!! it's a bummer because they work for me but bad for me.
The offer still stands- John 3:16

Regular Member

Date Joined Jun 2013
Total Posts : 25
   Posted 12/31/2013 11:51 AM (GMT -6)   
My rheumy was thinking about using it for me, but couldn't because I am allergic to asprin and its in the same class. So I am on high doses of ibuprofen instead--blah!


Regular Member

Date Joined Feb 2011
Total Posts : 399
   Posted 1/1/2014 11:08 AM (GMT -6)   
There are some drawbacks to the Prednisone, but it's been the best drug for me. I have exhausted all possibilities, even Benlysta. I don't like the side effects of Prednisone, but it really helps to manage my Lupus and keep the flares at bay. Everyone is different. There doesn't seem to be the same magic bullet for everyone....wish there was :-).

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