Anti-RNP Level

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CHAWNIE
Regular Member


Date Joined Jun 2013
Total Posts : 30
   Posted 4/29/2014 8:58 PM (GMT -6)   
I haven't posted in a while. Last year I tested positive for ANA (unk titer, three times) and positive for Anti-RNP (1.3 level). I was told to wait a year to have blood tests drawn again for my Rheumy.

Recently my ANA was negative but my Anti-RNP level is now 4.8. Is it normal for the ANA to go from positive (3 times) to negative. Also is it normal to just have an elevated Anti-RNP level?

My symptoms within this last year have been: rash in/on left ear, rash on right eyelid, eczema in hairline, periodic swelling on hands and feet, shortness of breath/achiness in chest, achiness under right ribcage near my liver, abdominal cramping/bloating, indigestion, ovaries achy and tender at times, fatigue, feel like I don't get enough sleep, etc.

Any ideas what my issue could be? What were your Anti-RNP levels?

Chantal

couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14475
   Posted 4/29/2014 9:20 PM (GMT -6)   
My rheumy says that ANA levels fluctuate. He believes that if you meet the required 4 out of 11 indicators you definately have lupus.
Joy
Lupus, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, OA, Depression, Allergies, and benign familia tremors

When life throws you lemons....
Pick them up and throw them right back at them! :))

CHAWNIE
Regular Member


Date Joined Jun 2013
Total Posts : 30
   Posted 4/29/2014 9:35 PM (GMT -6)   
Thanks! My Rheumy said that it may have been a false positive, I don't think so since it was positive three times and only negative once. Have your Anti-RNP levels been elevated?
Chawnie
37yrs
History: 2002 positive for antiphospholipid antibody, Ectopic pregnancy. 2005 Placental Abruption with son (lost him), after birth positive for Anticardiolipin antibody. No longer positive. 2007 gave birth to beautiful daughter. 2012 miscarriage. 2013: ANA +, RNP +

Symptoms: heart palpitations, lightheaded, fatigue, body aches, headaches

couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14475
   Posted 4/30/2014 12:09 AM (GMT -6)   
Mine hasn't been elevated any during any of my blood tests. My niece did test high in recent blood work, but no symptoms yet. We're keeping our fingers crossed on that one.
Joy
Lupus, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, OA, Depression, Allergies, and benign familia tremors

When life throws you lemons....
Pick them up and throw them right back at them! :))

CHAWNIE
Regular Member


Date Joined Jun 2013
Total Posts : 30
   Posted 5/12/2014 1:41 PM (GMT -6)   
I saw my Rheumy today regarding my symptoms and my elevated Anti-RNP (level of 4.8, anything over 1 is positive). Last year my level was 1.3, my Rheumy said that they aren't usually concerned until it gets to 8 or over. He checked my ANA and it was negative this time around. He basically had no answers as to why my Anti-RNP levels are increasing or if it will turn into anything more. Basically I have to wait it out and see him again in 6 months for more blood tests.

I am thankful that my other blood tests are normal but still don't feel up to well. I still have a lot of fatigue (I was given a pamphlet on insomnia), achiness throughout my body, headaches, hands/feet swell, rash on ear and eyelid.
Chawnie
37yrs
History: 2002 positive for antiphospholipid antibody, Ectopic pregnancy. 2005 Placental Abruption with son (lost him), after birth positive for Anticardiolipin antibody. No longer positive. 2007 gave birth to beautiful daughter. 2012 miscarriage. 2013: ANA +, RNP +

Symptoms: heart palpitations, lightheaded, fatigue, body aches, headaches

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7720
   Posted 5/12/2014 1:47 PM (GMT -6)   
It doesn't sound like this rheumy is treating your symptoms. It is well-known that many of the auto-immune diseases, like lupus, result in an extreme fatgiue that has nothing to do with insomnia.

Are you being treated with any medications at all?
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002
DIAGNOSING LUPUS & LUPUS RESOURCES
"Life is far too important to be taken seriously." - Oscar Wilde

CHAWNIE
Regular Member


Date Joined Jun 2013
Total Posts : 30
   Posted 5/12/2014 2:18 PM (GMT -6)   
No medications. I take Tylenol or Ibuprofren for achy joints/muscles. This Rheumy said he doesn't really know what is going on with my body, that time will tell. It is just a waiting game. He said if my blood tests showed more that he would have suggested Planquil but not at this time.

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7720
   Posted 5/12/2014 2:30 PM (GMT -6)   
He sounds like one of those old-fashioned rheumies that still thinks Lupus can be diagnosed by a blood test. A blood test is only ONE indicator of 11 that can point to Lupus, and you do not have to have bloodwork to have Lupus.

Check out www.lupus.org - check out the 4 of 11 symptoms that indicate Lupus. To find another Dr in your area check out the local lupus chapter and see what Drs work with them. I think a more up-to-date and Lupus-aware Dr would give you more help. This "wait and see" attitude sometimes backfires as it can get worse and permanent when some preemptive treatment would avoid all of that.
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002
DIAGNOSING LUPUS & LUPUS RESOURCES
"Life is far too important to be taken seriously." - Oscar Wilde

jan1952
Regular Member


Date Joined Mar 2014
Total Posts : 357
   Posted 5/14/2014 8:53 PM (GMT -6)   
Chawnie, elevated anti RNP level can be a sign of mixed connective tissue disease (MCTD), also known as Sharp's Syndrome. Check it out online and see what you think. That's been my diagnosis so far (from my primary), and I have a rheumatologist appt on May 28.

Best wishes to you--take care, and keep us updated.

Jan
"If there are no dogs in Heaven, then when I die I want to go where they went."
Will Rogers

Bsime
Veteran Member


Date Joined Apr 2006
Total Posts : 1342
   Posted 5/15/2014 4:03 PM (GMT -6)   
MCTD is not diagnosed unless the anti rnp antibody shows up. Maybe something to watch but if your symptoms continue you probably should get a 2nd opinion and talk about taking something to get your immune system under control. Whether or not you just have lupus or an overlap syndrome like MCTD treatment would probably be the same.

Labs alone do not mean you have something. Docs will look at clinical symptoms first and use labs or other tests to confirm a diagnosis and start treatment.

MCTD can present with symptoms of SLE lupus, scleroderma, polymyositis or sometimes RA or dermatomyositis. Every case is different and most likely you will not have all possible symptoms. I presented with lupus and then PM....

Bill
MCTD (SLE Lupus, polymyositis, scleroderma). Diagnosed 2005. Kidney, liver, GI tract, dysphagia, raynauds, barretts esophagus, quadriplegic in 2005. Recovered and now active in downhill skiing, golf, hiking. Meds: amlodipine, benezapril, omeprazole, potassium, folic acid, vitamins, maxide.

Remain Optimistic and you can overcome.

CHAWNIE
Regular Member


Date Joined Jun 2013
Total Posts : 30
   Posted 5/29/2014 11:54 PM (GMT -6)   
Jan - How did your Rheumy appt go?
Chawnie
37yrs
History: 2002 positive for antiphospholipid antibody, Ectopic pregnancy. 2005 Placental Abruption with son (lost him), after birth positive for Anticardiolipin antibody. No longer positive. 2007 gave birth to beautiful daughter. 2012 miscarriage. 2013: ANA +, RNP +

Symptoms: heart palpitations, lightheaded, fatigue, body aches, headaches

jan1952
Regular Member


Date Joined Mar 2014
Total Posts : 357
   Posted 5/31/2014 2:48 PM (GMT -6)   
Hello Chawnie, and thanks for asking about my appointment!

I posted a rather lengthy "description" of my visit--it's titled "rheumatology appointment" (how creative . . ;).
So maybe you can glance over that and see what I learned. I'm also going to post a new thread because I saw a dermatologist, too.

How are you doing? And that beautiful daughter of yours? :)

Jan
“Courage doesn't always roar.
Sometimes courage is the quiet voice at the end of the day saying, 'I will try again tomorrow.'"
- Mary Anne Radmacher
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