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New Member

Date Joined Jun 2014
Total Posts : 13
   Posted 7/28/2014 11:16 PM (GMT -6)   
I currently take MTX orally, however it destroys my stomach for three to 4 days afterwards. My Rheumy talked to me about the fact that they have shots for it now. I'm wondering if I misheard her and its actually infusions or does anyone know if they have MTX shots? She said it would bypass the issue I have with my stomach (whole reason I couldn't stay on plaquenil) and after being on MTX orally for the last 6 weeks. I just can't stand the sickness I feel after taken it anymore. Please let me know if anyone knows if MTX is in shot form or infusions. Thank you :)

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 7/29/2014 5:17 AM (GMT -6)   
It does come in shots now. Several posts recently mentioned it. I haven't had to do MTX yet.
Lupus, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, OA, Depression, Allergies, and benign familia tremors

When life throws you lemons....
Pick them up and throw them right back at them! :))

Barbara Lee
Veteran Member

Date Joined Sep 2003
Total Posts : 2889
   Posted 7/29/2014 9:23 PM (GMT -6)   
Yes, it's in shot form, you give yourself the shot weekly. I've been on them for over two years now. I take a VERY high dose of MTX because I have LGL Leukemia, as well as lupus. MTX is also used to help keep this type of leukemia stable but at much higher doses than for lupus.

I when I was on the lower doses for my lupus I rarely had side effects. Now that I'm on such a high dose, my fair is falling out, I've got terrible sores in my mouth, and I'm on anti nausea medication at least twice a day.

The medication, at least for me, comes in a vial. I have to draw it up into a syringe and change needles and then give myself the shot in thigh. I do this weekly, if I can answer any other questions, please feel free to ask.

DX- RA, Lupus, Fibro, LGL Leukemia, Obstructive & Central Sleep Apnea, Pulmonary Hypertension, Bells Palsy, Gastroparsis, Blood Clots, Glaucoma, Chronic Pericarditis & Pleurisy, Severe Anemia. Way to many medications to list.

New Member

Date Joined Jul 2014
Total Posts : 1
   Posted 7/30/2014 6:32 PM (GMT -6)   
I've been giving myself subq mtx injections once/week for the past 7 weeks for persistent pericarditis resistant to prednisone. They are teeny insulin type needles/syringes. You get no GI side effects as with the oral mtx. I have found that even on a low-ish dose 15mg/week it has turned me into a walking zombie and have had lower lip sores. May not be a sustainable option for me. I don't have any pericarditis pain tho. Still tapering down the prednisone at the same time.
Everyone is different tho and your experience may be smooth sailing. The oral mtx sounds like it is not a viable option for you.

Regular Member

Date Joined Jun 2012
Total Posts : 66
   Posted 8/3/2014 2:33 PM (GMT -6)   
I do the mtx shot weekly as well. Been on it for over a year now. I can honestly say, like you on the pill form, my poor stomach was a mess. I also have Acid reflux and let me tell you, it was rough. The shot form is much gentler as much as being on a chemo drug goes. I am not sure how if affects others, but myself, I am rather sluggish for a few days and my nausea is more tolerable. I will take that over not being able to venture far from the house if you know what I mean. I am currently having to go up on the dosage, so I imagine the side effects will go up as well. Any case, I will just have to tell myself-better than the pills.
One thing my doc did is to put me on folic acid to help with the nausea. Interestingly it does help.
Good luck

SLE RA Acid Reflux/GERD Costochondritis
Methotrexate shots, Plaquinel, Omeprazole, Folic Acid, Calcium Carbonate, Cholecaliferol, Celebrex, Allegra, Lactaid,

Ain't Life fun? :)
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