possible connection between different autoimmune diseases & genetics

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New Member

Date Joined Oct 2014
Total Posts : 4
   Posted 10/15/2014 9:00 AM (GMT -6)   
At a routine doctor appointment I had mentioned to my doctor that I've had some extreme fatigue and very severe joint aches and stiffness. . I thought it was hormonal because I'm also having hot flashes and night sweats. I'm only 37 so it's a little young for that but you never know. My doctor texted me for antinuclear antibodies and the results where positive with a titer of 1:320 speckled pattern. I did some research and found what this can indicate. Of the autoimmune diseases that have a speckled pattern lupus is the one my symptoms are most likely. I also have other symptoms that may relate to lupus, totalling 5 of the 11 criteria for a lupus diagnosis. Of the officiak diagnosis criteria symptoms I have:
1.joint aches
2.positive ANA test
3.recurrent mouth sores
4. Photosensitivity
5.protein in urine (in the past)

NOW, here's where the plot thickens and I need some ideas/thoughts -

While waiting 2 months to get in to an appointment the rheumetologist, I insisted my 20 year old daughter also be checked for ANAs because she also has joint pain and fatigue. She got her blood work results yesterday and was told she has pretty severe Rheumatoid Arthritis. Shes extremely upset, especially with it being so severe a such a young age. She's also stuck with a long wait to get into a specialist.

Im trying to understand how a mother/daughter had such close symptoms but different indicators in the blood. (All my stuff for rheumatoid was fine and she had no ANAs present to indicate lupus. While im fully aware no one can diagnose on here etc, does anyone have any thoughts or insight on this and what the genetic connection is or how this all works??

Another interesting tidbit bit that may or may not be related: last year it was discovered that my daughters gallbladder had basically died and was causing her pain (HIDE scan showed <1% function left. Ive also had periodic pain in the gallbladder area and recently had a 2 week bout with pretty severe pain. (My other complaint wheb I was at my doctor last time). Im still waiting for the ultrasound results but I know in my daughters case all tests and scans up until the HIDA was finally ordered where normal. It was quite a battle to finally get a doc to do the HIDA scan actually. They where baffled as to why a 19 year old healthy girls gallbladder would just die like that.
Any thoughts or Insight ob a possible connection? ?

Veteran Member

Date Joined Apr 2006
Total Posts : 1335
   Posted 10/15/2014 9:13 AM (GMT -6)   
Autoimmune diseases do run in families. Not necessarily the same diseases but genes are a factor and you can inherit genes that make your immune system susceptible to a disruption. Depending on what you are exposed to determines what you get.


Keep in mind that ana is present in many diseases and can be present even when there is no disease.

MCTD (SLE Lupus, polymyositis, scleroderma). Diagnosed 2005. Kidney, liver, GI tract, dysphagia, raynauds, barretts esophagus, quadriplegic in 2005. Recovered and now active in downhill skiing, golf, hiking. Meds: amlodipine, benezapril, omeprazole, potassium, folic acid, vitamins, maxide.

Remain Optimistic and you can overcome.

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 10/15/2014 11:58 AM (GMT -6)   
My mother and sister are both diabetics. My mother has mild RA and MDS. I have RA and lupus. They are all considered autoimmune diseases.
Lupus, RA, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, Depression, Allergies, and benign familia tremors

When life throws you lemons....
Pick them up and throw them right back at them! :))
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