Blood test results and I am somewhat confused

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LAWCHICK
Regular Member


Date Joined Jul 2010
Total Posts : 468
   Posted 2/19/2015 2:58 PM (GMT -6)   
I haven't been doing too well health wise lately so my primary ordered some blood test. My ANA has now come back negative (it has been positive in the past). I am shocked by that because I have been so sick lately and I had been off my plaq. My C4 was low as usual however now my C3 is low also. My c3A Fragment is also low and I don't even know what the heck that is. My Doctor isn't going to go over these results until Monday with me. Has anyone had similar testing or a negative ANA with low C3 C4?

couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14475
   Posted 2/19/2015 9:57 PM (GMT -6)   
ANA can rise and fall. A lupus diagnosis is based on the 11 indicators list.
Joy
Lupus, RA, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, Depression, Allergies, and benign familia tremors

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Pick them up and throw them right back at them! :))

LAWCHICK
Regular Member


Date Joined Jul 2010
Total Posts : 468
   Posted 2/21/2015 9:05 PM (GMT -6)   
couchtater said...
ANA can rise and fall. A lupus diagnosis is based on the 11 indicators list.


I know it can go Neg to positive but I was just really surprised mines was negative right now since I have been so sick. My. C4 and C3 is low so I must be in a flair I would think.

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7720
   Posted 2/21/2015 9:20 PM (GMT -6)   
ANA numbers are not related at all to level of disease activity, it doesn't even have to be positive for a Lupus diagnosis! C3 & C4 aren't related all that much to disease activity, either. Weird, I know, but these are used more in helping diagnose an auto-immune disease rather than in helping treat it.

However if you are experiencing a lot of symptoms your inflammation markers are probably high. My Drs (rheumies) haven't ever bother to keep testing ANA, C3 & C4 levels once they were clear on the diagnosis, instead activity is/was almost exclusively tracked by inflammation markers.

Unless your Dr is still unclear as to the diagnosis??
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002
DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde

LAWCHICK
Regular Member


Date Joined Jul 2010
Total Posts : 468
   Posted 2/22/2015 9:00 AM (GMT -6)   
Lynnwood said...
ANA numbers are not related at all to level of disease activity, it doesn't even have to be positive for a Lupus diagnosis! C3 & C4 aren't related all that much to disease activity, either. Weird, I know, but these are used more in helping diagnose an auto-immune disease rather than in helping treat it.

However if you are experiencing a lot of symptoms your inflammation markers are probably high. My Drs (rheumies) haven't ever bother to keep testing ANA, C3 & C4 levels once they were clear on the diagnosis, instead activity is/was almost exclusively tracked by inflammation markers.

Unless your Dr is still unclear as to the diagnosis??


My Dr seems pretty positive on lupus. I see them tomorrow so I guess I will ask what the point of these blood test were. At the last appointment she just mentioned bloodwork quickly at end at end and told me to pick up the script at window. I read somewhere that c3 and c4 low show active disease so maybe that's why she ordered it?
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