ANA numbers are not related at all to level of disease activity, it doesn't even have to be positive for a Lupus diagnosis! C3 & C4 aren't related all that much to disease activity, either. Weird, I know, but these are used more in helping diagnose an auto-immune disease rather than in helping treat it.
However if you are experiencing a lot of symptoms your inflammation markers are probably high. My Drs (rheumies) haven't ever bother to keep testing ANA, C3 & C4 levels once they were clear on the diagnosis, instead activity is/was almost exclusively tracked by inflammation markers.
Unless your Dr is still unclear as to the diagnosis??
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002DIAGNOSING LUPUS & HW's LUPUS 101
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