Welcome to our forum alysen101. I'm sorry to hear of your multiple diagnoses. One important thing to know is that one often needs to take Plaquenil for months before it begins working. Also Lupies are often on Plaquenil for years. I've been taking it since 2005 and even with the mountain of other meds I take, I still feel ill if I forgot to take it. It has few side effects.
As for prednisone the list of side effects is long. The ones I hate most are crazy insomnia (kind of a trade off for the energy it gives you) and many of us gather movies, books, magazines, etc when we are starting a prednisone taper to make the insomnia easier; Moon Face- yep your cheeks puff up like a toad; and Buffalo Hump- this is where the area of your upper back, just below the nape of your neck, develops a large fat pad.
You may want to buy "The Lupus Book" by Daniel Wallace, MD. It has loads of info and I highly recommend it.
Oh, like Lynnwood I also don't know what MTHFR is, but I'm sure it's not an acronym for the curse word I'm thinking of, so let us know!
Please feel free to vent, tell us how you're doing, and reply to your fellow Lupies. Love, Butterflake
SLE '05, Sjogrens, fibro, Raynaud's, major depressive disorder, CNS problems, GERD, angina, 1st stage kidney disease. Many meds: better living through chemistry