I took Imuran for about
6 months with no side effects. Unfortunately, it didn't do anything for me.
There are 3 meds that are considered somewhat the same level of treatment, these are Imuran, Cellcept, and MTX. It is not known which of these will work for a particular Lupus patient, instead it is a bit of trial-and-error.
When the Imuran didn't help me any, we moved along to Cellcept which has been my "miracle drug" that pushed my Lupus into a quiet phase. (Rheumatologists don't use the word "remission".)
I don't recall having any issues with depression that were linked to plaquenil. However, many of us do have depression that is linked to Lupus itself and to the changes it brings to our lives. It can be helpful to consult with a therapist who is familiar with chronic illness, even though these can be difficult to locate.
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde