I'm new here as well...diagnosed Sept 2 same as Cheryl!
I started 400 mg Plaquenil, (200 am & pm) Sept 3rd. Only a couple hours after I took the 1st dose I was miserable with GI issues (diarrhea, cramping, bloating & gas...so sorry!). Since I'm already on Imuran (immune suppressant) for another autoimmune condition, I was worried that I would be in trouble if I couldn't tolerate the Plaquenil for the SLE.
The good news is that the 2nd day was better and eventually things calmed down...although bloating/gas is still a problem I'm trying to deal with. I have had some nausea that was relieved by Zofran, but that has improved as well.
The SUPER GOOD NEWS is that on the 27th day the bone crushing fatigue I've had since February finally improved!!! I've had more up than down days since then, and think I'm finally seeing the light at the end of the tunnel!
Hope this helps
Post Edited (Amethyst4) : 10/16/2015 1:16:39 PM (GMT-6)