Fluctuating Antibodies

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Mrs. Brady
Regular Member


Date Joined Feb 2015
Total Posts : 238
   Posted 2/5/2016 1:17 PM (GMT -6)   
Do your antibodies fluctuate? I read that it is normal for the levels to fluctuate but is it normal to have them go from moderate positive to weak positive to negative (See RNP) or weak positive to negative to moderate positive (histone)? For reference, here are my test results and dates with the ranges that I am curious about:

Histone - 12/14 1.5; 2/15 0.9; 8/15 2.1 (Waiting for lab results from this week)
Reference Ranges
0.9 Units or less ............ Negative
1.0 - 1.5 Units .............. Weak Positive
1.6 - 2.5 Units .............. Moderate Positive

RNP - 12/14 62; 2/15 30; 8/15 30; 2/16 18
Negative <20
Weak Positive 20 - 39
Moderate Positive 40 - 80
Strong Positive >80

Smith - 12/14 36; 2/15 33; 8/15 34; 2/16 29
Negative <20
Weak Positive 20 - 39
Moderate Positive 40 - 80
Strong Positive >80

C3 and C4 are still low but are a bit higher from August, currently lupus is "quiet".

Thanks for any and all input, I appreciate it!
Hoshimoto's Hypothyroidism DX Oct 1997
Left Sided UC DX Nov 2013
GERD DX Nov 2013
SLE, DX Sept 2015
Medications - Synthroid, Hydrocort Enemas; Prilosec; Poly-Iron 150 Forte; Plaquenil; Vitamin D
Past Meds: Lialda - developed severe joint pain, initial DX DILE, discontinued mesalamine, symptoms subsided but returned - less severe, DX SLE

couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14475
   Posted 2/6/2016 12:04 AM (GMT -6)   
Sounds like everything is increasing, but I'm no doctor.

I wouldn't worry if everything is quiet right now. Enjoy it while it lasts.
Joy
Lupus, RA, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, Depression, Allergies, diabetes, and benign familia tremors

When life throws you lemons....
Pick them up and throw them right back at them! :))

Bsime
Veteran Member


Date Joined Apr 2006
Total Posts : 1342
   Posted 2/17/2016 10:50 PM (GMT -6)   
Autoantibody tests do but are not necessarily an indication of disease activity which is why most docs don't test after getting a diagnosis. They do go up and down. How you feel is more of an indicator of what's going on.

RNP is tested to see if you have an overlap syndrome, MCTD. Once it is positive it is usually not tested again. No reason. Often other tests are ordered to confirm a diagnosis....like a biopsy or some other diagnostic test.

Bill
MCTD (SLE Lupus, polymyositis, scleroderma). Diagnosed 2005. Kidney, liver, GI tract, dysphagia, raynauds, barretts esophagus, quadriplegic in 2005. Recovered and now active in downhill skiing, golf, hiking. Meds: amlodipine, benezapril, omeprazole, potassium, folic acid, vitamins, maxide.

Remain Optimistic and you can overcome.

Lynnwood
Veteran Member


Date Joined May 2005
Total Posts : 7720
   Posted 2/18/2016 10:04 AM (GMT -6)   
Like Bill says, antibody tests are not usually repeated.

Lupus activity is more often followed by 1) symptoms and 2) inflammation markers in the blood, and 3) sometimes, but not always, ANA

Inflammation markers include: The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and some others.
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002
DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde

Mrs. Brady
Regular Member


Date Joined Feb 2015
Total Posts : 238
   Posted 2/18/2016 2:06 PM (GMT -6)   
Thanks for the response, I guess in the back of my mind I was hoping somebody would say, "no, they don't fluctuate, looks like it wasn't lupus after all". I know, I know, wishful thinking and perhaps a bit of denial!
Hoshimoto's Hypothyroidism DX Oct 1997
Left Sided UC DX Nov 2013
GERD DX Nov 2013
SLE, DX Sept 2015
Medications - Synthroid, Hydrocort Enemas; Prilosec; Poly-Iron 150 Forte; Plaquenil; Vitamin D
Past Meds: Lialda - developed severe joint pain, initial DX DILE, discontinued mesalamine, symptoms subsided but returned - less severe, DX SLE

Lynnwood
Veteran Member


Date Joined May 2005
Total Posts : 7720
   Posted 2/18/2016 4:45 PM (GMT -6)   
No problems -- after 14 years, the last few with my Lupus really quiet...

I still expect that big phone call --

"It wasn't Lupus, it was just you didn't eat enough sugar, here, have a cookie!"
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002
DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde
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