Positive ANA but negative for SLE

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New Member

Date Joined Mar 2016
Total Posts : 15
   Posted 9/2/2016 5:46 PM (GMT -6)   
I had some blood tests a couple of weeks ago.

My antinuclear antibodies result came back as

1:320 homogeneous pattern.

I had further testing for SLE and a few other autoimmune diseases, came back negative for all. I thought this was good until the doctor mentioned that I'd need to retest in 6-12 months, or see a rheumatologist. I didn't understand why until I looked into it further, that the ANA test can show something before it develops. Is it possible to have a positive ANA result but nothing ever develop? Should I do anything further at this point? So confused!

The doctor I saw wasn't my usual doctor or clinic, but I have a copy of all my results so I'm thinking maybe next time I'm at my regular doctor, I'll give them a copy and see what they think.

Veteran Member

Date Joined May 2005
Total Posts : 7723
   Posted 9/2/2016 10:10 PM (GMT -6)   
Do you have any kind of symptoms that are bothering you? Why were the tests done?

Note that there are NO DEFINITIVE tests for SLE, so "coming back negative for all" means nothing. Lupus is diagnosed by having at least 4 of 11 diagnostic symptoms, not by blood tests. ANA is only one of the 4.

Typically, four or more of the following criteria must be present to make a diagnosis of systemic lupus.

The “Eleven Criteria”

1.Malar rash: butterfly-shaped rash across cheeks and nose
2.Discoid (skin) rash: raised red patches
3.Photo-sensitivity: skin rash as result of unusual reaction to sunlight
4.Mouth or nose ulcers: usually painless
5.Arthritis (non-erosive) in two or more joints, along with tenderness, swelling, or effusion. With non-erosive arthritis, the bones around joints don’t get destroyed.
6.Cardio-pulmonary involvement: inflammation of the lining around the heart (pericarditis) and/or lungs (pleuritis)
7.Neurologic disorder: seizures and/or psychosis
8.Renal (kidney) disorder: excessive protein in the urine, or cellular casts in the urine
9.Hematologic (blood) disorder: hemolytic anemia, low white blood cell count, or low platelet count
10.Immunologic disorder: antibodies to double stranded DNA, antibodies to Sm, or antibodies to cardiolipin
11.Antinuclear antibodies (ANA): a positive test in the absence of drugs known to induce it.

Definitely give the results to your regular Dr!
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002
"Life is far too important to be taken seriously." - Oscar Wilde

New Member

Date Joined Sep 2016
Total Posts : 1
   Posted 9/2/2016 10:19 PM (GMT -6)   
I have many autoimmune diseases & not 2 of them were diagnosed at the same time. Nor did my GI tell me after having Crohn's for almost 25 years, that Crohn's & Hashimoto's (effects thyroid gland &a thyroid function) pretty much lay hand in hand. A reg Family Physician told me that they did! Apparently when u have one autoimmune, it's inevitable u will get more over your lifetime. I had Crohn's for 25yrs then developed Lupis,had it almost 2yrs & developed Hashimoto's & somewhere in there I developed RA. I do have my dr's to run random tests for other autoimmune all the time, especially if I have an unexplained new symptom.
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