Raised RNP and SSA

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Melissa D.
Regular Member


Date Joined Aug 2008
Total Posts : 432
   Posted 10/31/2016 2:32 PM (GMT -7)   
Hello All,

Having SLE for over 20 years and my disease unfortunately becoming more active as time goes on, I have learned to keep a close eye on my labs. My last labs a few weeks ago have left me quite concerned because there are several things that are abnormal, such as:
RNP(sm) 114 (normal is 0.00 - 83)
SSA(ro) 231 (normal is 0.00 -91)
C4 10 (normal 16 - 47)

There are other labs that are off such as my lymphs, neutrophils, and my SGOT and SGPT were slightly raised as well as my protein, these have gone up and down that is not unusual. The RNP and SSA, however are just recently increasing, this is the worse I can recall these counts being. I sent a message to my doctor's office and his nurse called me back and said "the doctor said this means your disease is increasingly more active." Okay?! But active with what? When I do research I am concerned that it could be Liver or Kidney disease!

I have been very blessed that I have not experienced kidney disease, I have had a few issues with my liver over the years, but it has been able to be controlled and there has been no activity or suspect of activity in recent years. And when I did deal with that my liver counts were over 300.

I don't see my doctor again until December 21st, I have tried sending another message to see if I could get a more clarified answer and to see if I need to have labs drawn again maybe 6 -8 weeks from the last draw to see where they stand.

Do y'all think I am over reacting or over thinking things? I have also read that it is not typical for a person who has had SLE this long who has not developed kidney disease to develop it. Your experience, thoughts?

Thanks in advance;

Melissa

Post Edited (Melissa D.) : 11/1/2016 4:12:59 AM (GMT-6)


Bsime
Veteran Member


Date Joined Apr 2006
Total Posts : 1331
   Posted 10/31/2016 3:41 PM (GMT -7)   
Lupus can attack both kidneys (common and often a presenting symptom) and liver (less common. I have had both. Kidneys were a presenting symptom and liver 9 years later. Treatment to suppress the immune system works and in some cases on going therapy to control hypertension for kidney problems.

Lupus is also attacking my platelets and suppression using steroids or other means is necessary. Just had my 2nd liver biopsy last week in 2 years due to false reading on a screening test. Labs are perfect, feel ok, and relieved that news of the latest biopsy shows no further damage meaning I do not need to be on long term treatment at this time due to lupus hepatitis.

Lupus is infinitely complicated but I just keep slugging through the problems and not live in fear or project the future. I also have polymyositis which is less complicated but totally disabled me and almost cost me my life 11 years ago. Left me quadriplegic but I have recovered and just bought a new pair of skis for the winter season. Life is different but good and I refuse to live in fear.

Bill

Melissa D.
Regular Member


Date Joined Aug 2008
Total Posts : 432
   Posted 10/31/2016 4:53 PM (GMT -7)   
Thanks for the post Bill. You are always a wealth of knowledge and positive reinforcement!
Married the love of my life, mother of 2 beautiful adult children, 1 amazing daughter in law, and 1 grandson who is truly a gift from God! lupus SLE 1996, sjorgrens, raynauds. My worst nightmare was imagined when my son was diagnosed with RA and lupus NPSLE at 19. I try to live life as though everyday is a blessing, otherwise it would be hard to put one foot in front of the other...hugs

Melissa D.
Regular Member


Date Joined Aug 2008
Total Posts : 432
   Posted 10/31/2016 7:40 PM (GMT -7)   
One other tidbit I guess is the reason this has me asking my doctor again and questioning my labs is because for the last few years I've had a really, really hard time gaining weight and suddenly that's changed over night. I literally could not get above 90lbs, then the last couple weeks I've slowly begun gaining, which is good, I went from 88 to 92 and stayed there for a few days. Today I weighed myself and I'm 101!!! What 9 pounds essentially over night?!?! Something is not right! I have not changed my diet or medicines in any way and tonight I feel like my face is puffy.

couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14475
   Posted 10/31/2016 9:24 PM (GMT -7)   
Sounds like some fluid retention going on.
I can fluctuate 10 pounds in two days if I don't take my lasix.
Joy
Lupus, RA, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, Depression, Allergies, diabetes, and benign familia tremors

When life throws you lemons....
Pick them up and throw them right back at them! :))

Melissa D.
Regular Member


Date Joined Aug 2008
Total Posts : 432
   Posted 11/1/2016 11:04 AM (GMT -7)   
I agree Joy, it does sound/feel like fluid retention. I do. It currently take a lasix but if things continue like this it is something my doctors and I will have to discuss.

The doctor also emailed me back stating he does not believe the high RNP and SSA are a sign of organ damage at this time. He was in agreement that we should go ahead and run labs again to see what my what my counts look like now. Thankfully, I was in San Antonio today so I was able to stop by his office.

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7556
   Posted 11/1/2016 11:40 AM (GMT -7)   
Not changed your diet or medications -- have you changed your exercise? Or your location?

If you aren't moving around as much you could easily retain water -- or if you are in a different climate. I always get "puffy" when I visit south Florida, dunno' why... maybe it's extra salt in the tap water?

I've also found that scales can be wildly inaccurate! One day this summer I weighed 4 times in 5 minutes, had 167, 169, 175, and 182!!! The day before I was 176...
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2000
DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde

Melissa D.
Regular Member


Date Joined Aug 2008
Total Posts : 432
   Posted 11/1/2016 1:34 PM (GMT -7)   
No Lynnwood, haven't changed my diet or any of my meds. And as far as activity goes, I've actually been more active as of late. Not that I've been feeling better, just a lot of things going on and no time to really slow down and lay around. I'll just chalk it up to a fluke as far as the weight gain goes. I know it's just got to be fluid retention and it'll go away quickly.
Married the love of my life, mother of 2 beautiful adult children, 1 amazing daughter in law, and 1 grandson who is truly a gift from God! lupus SLE 1996, sjorgrens, raynauds. My worst nightmare was imagined when my son was diagnosed with RA and lupus NPSLE at 19. I try to live life as though everyday is a blessing, otherwise it would be hard to put one foot in front of the other...hugs
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