Welcome to HW!
Plaquenil sometimes gives us a few days of GI issues when we first start it. Hang in there, that should pass after 5-7 days.
I personally have not taken MTX, so don't have any comments on that.
I have taken vaccines as they've been suggested to me -- usually the rheumy has a pretty good sense of how I'm doing and doesn't suggest vaccines when I'm flaring in some manner. If I was feeling ill at all, I might wait till I was feeling better. And if a Dr other than my rheumy suggests something, I clear it with the rheumy first. (The CDC suggests the Shingles Vaccine and the Pneumonia Vaccine be staggered 4 weeks apart.)
I'm guessing you mean 'Restless Leg Syndrome' - sorry, don't have that either! lol Maybe someone else has a comment on it.
Let us know how things go!
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2000DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde
Post Edited (Lynnwood) : 6/19/2017 2:33:11 PM (GMT-6)