Plaquenil is used to inhibit disease progression - most of us are started on it immediately and need to remain on it long-term. Takes 2-3 months to build up in your system.
Generally a rheumy will then choose one of these three; Imuran, Cellcept, or MTX to inhibit the over-active autoimmune system that is Lupus. There are no clear guidelines that recommend starting with one of these over the others -- and it's hit-and-miss which one will work best for any individual patient. It's simply trial and error!!
For me, Imuran did nothing. No positive results, and no side effects. So my Dr moved on to Cellcept, which was a miracle medication for me. Others here have gotten great results from either Imuran or MTX.
PS. I see that in June you were asking about
MTX (Methotrexate). Did you end up trying that?
I found that following my Dr's instinct/experience/training gave me good results. The Dr knows exactly how your individual manifestation of the disease is presenting, what has already been tried, how you reacted to it... all of this information goes into how s/he chooses the next course of action.
Let us know how it goes!
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2000DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde