I'm popping over from the Crohn's forum. I've been dealing with inflammatory arthritis, muscle pain, Raynaud's, Erythromelalgia and sudden onset hypertension within the last few years. My initial problem was the arthritis and joint pain which was treated as an extra-intestinal manifestation of Crohn's. about a year and a half ago I went to my first Rheumatologist appointment and had many blood tests run looking for a connective tissue disorder (I can't recall them all but can look them up) and the only positive test was a low positive for anti-histone antibodies. At the time the Rheumatologist continued treating the pain as seronegative arthritis. I recently went for a second opinion because I was having more problems and wasn't confident with the original Rheumy. This second doctor ordered some lab work; ENA, anti-dsdna, CBC, ESR, CRP, C3 and C4 complement. This time the anti-dsdna test was positive with a titer of 1:20 (this lab uses a 1:10 as a positive cutoff) everything else was within normal limits. I guess I'm wondering what this titer level means, I plan to call the doctor about the result tomorrow, and what I should possibly do next. I am currently on Plaquenil for the joint issues, but this doctor assumed the problem was Crohn's related when I first saw him.