Posted 5/25/2007 9:57 PM (GMT -7)
From what I read, it sounds like clumped platelets indicate clotting of your blood, I wonder if this is like high sed rate? The stuff below is from the Merck manual online, which is what docs used to use anyway. I would ask my doc, there is stuff you can take to thin your blood. Thrombocytopenia is a really bad problem and I think there is other stuff that's wrong with your blood as well, I don't know. I asked the doc about it and they said,if you had it, you'd know. I know that I was at high risk for it on interferon, and I was really really sick and I didn't get it, got everything else though. I think you get very sick with it, but don't know. But blood clots aren't good either. I would call doc and get some kind of answer and tx, especially because you have anemia.
The stuff below is from here:
Formation of a clot also involves activation of a sequence of blood clotting factors that generate thrombin. Thrombin converts fibrinogen, a blood clotting factor that is normally dissolved in blood, into long strands of fibrin that radiate from the clumped platelets and form a net that entraps more platelets and blood cells. The fibrin strands add bulk to the developing clot and help hold it in place to keep the vessel wall plugged.
The relationship between drugs and the body's ability to control bleeding (hemostasis) is complicated. The body's ability to form blood clots is vital to hemostasis, but too much clotting increases the risk of a heart attack, stroke, or pulmonary embolism. Many drugs, either intentionally or unintentionally, affect the body's ability to form blood clots.
Some people are at high risk of forming blood clots and are intentionally given drugs to decrease the risk. Drugs may be given that reduce the stickiness of platelets, so that they will not clump together to block a blood vessel. Aspirin, ticlopidine, clopidogrel, abciximab, and tirofiban are examples of drugs that interfere with the activity of platelets.
Other people at risk of forming blood clots may be given an anticoagulant, a drug that inhibits the action of blood proteins called clotting factors. Although often called "blood thinners," anticoagulants do not really thin the blood. Commonly used anticoagulants are warfarin, given by mouth, and heparin, given by injection. People who take these drugs must be under close medical supervision. Doctors monitor the effects of these drugs with blood tests that measure the time it takes for a clot to form, and they adjust the dose on the basis of test results. Doses that are too low may not prevent clots, while doses that are too high may cause severe bleeding. Another type of anticoagulant, low-molecular-weight heparin, does not require as much supervision. Lepirudin, bivalirudin, and argatroban are newer types of anticoagulants that directly act on thrombin, a protein that helps induce clotting.
If a person already has a blood clot, a thrombolytic (fibrinolytic) drug can be given to help dissolve the clot. Thrombolytic drugs, which include streptokinase and tissue plasminogen activator, are sometimes used to treat heart attacks and strokes caused by blood clots. These drugs may save lives, but they can also put the person at risk of severe bleeding. Surprisingly, heparin, a drug given to reduce the risk of clot formation, sometimes has an unintended activating effect on platelets that increases the risk of clotting (heparin-induced thrombocytopenia).
Estrogen, alone or in oral contraceptives, can have the unintended effect of causing excessive clot formation. Certain drugs used to treat cancer (chemotherapy drugs), such as asparaginase, can also increase the risk of clotting.
"...brain, what is brain?"
--Kara, one of the "givers of pain and delight", aka woman of Sigma Draconis VI, "Spock's Brain" episode 56 season 3 of Star Trek--I'm not a trekkie but this one was funny!