Wow! Such great replies, i thought it was a pointless post, but you guys here are making me feel very welcome, and thanks you redrose because your advice was like none if ever been given before. and all of you too. Now im a little scared, cuz i said i stopped taking the plaquenil, and my mom doesnt know that, but after reading your replies, im gonna keep taking it. in fact, im popping a pill into my mouth right now. yes, my mom has lupus, and she used to take prednisone and now she is taking plaquenil, she had some heart involvemnt when i was born, and she almost miscarriaged, and she has arthritis, and all the other symptoms i mentioned in my post. here ANA got positive a little while ago, because hers had been negative for some years now, so i guess she is out of remission. iv had the ANA test like three times now, and its always negative. my RF is 2 points away from beinng considered mild arthritis, but i guess the doctor didnt do anything about the joints because it was really mild inflammation, which i dont think makes sense because i have extrem e pain at times, sometimes during the middle of the night, theyre like shocklike, and shooting pain, in my wrists, elbows, ankles, knees, and sometimes the middle of my thigh. my muscles twitch like all the time, i see it moving its so freaky, and sometimes my thumbs starts twitching. also, im having sore muscles for no reason when i wake up in the morning, that has happened about three times already, but the doctor is only making me take half a pill of plaquenil every day. its so frustrating. ive had two head mris because i have alot of migraines, almost daily, and it was negative, and my rheumy didnt even diagnose me with migraines or gave me painkillers for that. because OTC never works for me. oh yeah, and i told her i was tired all the time, and she said it was just stress from school. now that school has been over for the past two weeks, my symtpoms are the same or worse. i hate when they say its stress or that im depressed. okay well im venting lol anyway thanks for yalls great replies!