Here's another link that has some possible negative side effects. I remember when SAMe came out, it was real big, then you heard nothing. It says the mechanism of action is unknown. It seems to act like a tricyclic antidepressant, so it might be hard to tell if it is actually helping or just making you feel better--and that may be enough. Didn't see a mention of lupus, but it is a treatment for hypochondriasis and fibro of all things.
I hope it works for you. I know the plaquenil was a real struggle. DHEA is something I'm curious about as I have endo problems, I hear mixed reviews on the thyroid site, some great, some that it does nothing, one or two it made real sick.
It sounds like both are real strong, so be careful. I'm really happy that the new rheumie doesn't seem like a total jerk, it takes so long to switch.
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments