protein in urine

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Regular Member

Date Joined Aug 2006
Total Posts : 47
   Posted 8/3/2007 3:51 PM (GMT -6)   
Hi I have a question. about a year ago I was very very ill and my pulmonologist thought I might have Lupus. I started seeing a Rheumy about 4 months ago and she diagnosed me with RA and fibro. I work in a lab and have been doing urines on myself once a week for the past few weeks and I have had protein in my urine everytime. I tried to call my dr today but she is out of the office and will be for the next week. She has said that she didn't think I had lupus but I have been having sores on the roof of my mouth and a rash on my face both of which went away after being on Plaquanil for 2 months. My ANA is negative but my RA is positive. I know alot of you have both so I was wondering if the protein could be from the RA or if I should still be worried about Lupus. My illness started with paricarditis and progressed from there to the muscle and joint pain and being sicker than a dog for months. I actually could not get outta bed for weeks at a time. The doc said all of this was the RA. Any advise you can give would be great.

Veteran Member

Date Joined Jan 2004
Total Posts : 4151
   Posted 8/3/2007 4:04 PM (GMT -6)   
Hi Susan,

I don't have RA but I do know that it is a close relative of Lupus. I'm not sure if spilling protein is part of RA however I'm sure there will be others here to tell you whether yes or no. While it is not uncommon to have a negative ANA with Lupus, it is not impossible either. With a face rash and mouth sores, those are very common symptoms in Lupus. Did your doc test you for the individual ENA's as well? Anti-Ro, Anti-La, anti-dsDNA, Anti-Sm, etc.? Sometimes any one of those can come up positive even with the ANA negative. Of course, like I said, your symptoms could stem from RA also, I'm just not sure. Welcome to the forum. I'm sure you'll get much more helpful answers than I have given you. :-)

Take Care
Co-Moderator ~ IBS Forum
Co-Moderator ~ Lupus Forum 
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007
Meds: Plaquenil 400mg, Chlorzoxazone 500mg, Lyrica 50mg, Protonix 40mg, Naproxen 1000mg, Klonopin 2mg/day (tapering to PRN), Miralax 17g, Supplements

Veteran Member

Date Joined Apr 2006
Total Posts : 1344
   Posted 8/4/2007 11:55 PM (GMT -6)   
Proteinuria is a common condition with lupus but I don't know about RA.  I had it and it went away after taking lisinopril.  The swelling I had also went away.
I would advise you to see a nephrologist and get it checked out. Whatever is causing it should be treated so that you do not have kidney damage.  Mine had early stage 2 but have recovered fully and they function normally now. 
Mixed connective tissue disease (systemic lupus, scleroderma, polymyositis), Raynauds phenomena, Hypertension, Barrett's esophagus.
Meds: prednisone (7mg & tapering), 100mg imuran, lisinopril 40mg, maxide 37.5/25mg, norvasc 5 mg, folic acid, potassium, aciphex 20mg, multi vitamins.
Maintain your optimism and you can beat the odds.
"Although the world is full of suffering, it is also full of the overcoming of it."  Helen Keller

Audrey Ann
Veteran Member

Date Joined Jul 2005
Total Posts : 815
   Posted 8/5/2007 10:26 PM (GMT -6)   
Greetings! I have both lupus and RA and I frequently have protien in my urine. I was told that the protien was asymptom of my lupus - not the RA. Also, I am ANA negative. So, I wonder if you might have lupus, too. Lupus and RA are so related and the treatments are quite similar.

Good luck!
Audrey Ann
Diagnosis: Lupus and RA
Medications: Plaquenil (400 mg), RelafenMethotrexate Injections, Folic Acid, Aldactizide for High Blood Pressure, Lipitor for High Cholesterol, Actonel for Osteopenia, and Allegra & Patonel Eye Drops for Allergies.


Veteran Member

Date Joined Jan 2005
Total Posts : 659
   Posted 8/6/2007 12:03 AM (GMT -6)   

Hi Susan,

I'm sure you know that protein in the urine is frequently an indication of a kidney problem and it needs to be checked out. It could be lupus, or kidney disease, or perhaps nothing, but you should look into it further. Let us know how you make out.


DX: Kidney Disease, questionable Lupus Nephritis 2002
DX: Raynaud's Phenomenon and Lupus 2005
DX: Anorexia and Hypokalemia 2006
meds: plaquenil, lasix, klor-con

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