I'm sorry this is happening to you and I don't know how you usually handle prednisone, but I'm concerned because you take lyrica and this can be very bad. Lyrica, which is very similar chemically to neurontin and feelings of depression on these drugs can be very serious, even if you are having other odd non-depressed emotional states as well. Often it can take several months for a person to develop an allergy or intolerance to a drug, I have many allergies or intolerances whatever you want to call them, to drugs due to my liver. Often, the liver puts up with the overload of medication for a while, then after a while, the damage from the medications causes the liver not to be able to metabolize them as well, they back up and you sort of OD on them because you aren't metabolizing them correctly.
That's why I harp on the liver. It may take years for the liver to be damaged, but once you have a problem like me, its extremely hard to turn it around. Please call the doc about the lyrica, I can't take lyrica at all, neither can my mom, who was on neurontin but is still having problems. These meds are very strong. Some people take them no problem, I guess. I haven't met any that have been on it more than a year. My doc had to up my klonopin to get me off it without having a seizure so you can't just quit it and it may not be the problem.
On another note, I get like totally!!!!! every single time from prednisone when it wears off and a shot only lasts about a day or two, just wonderful beautiful days, then I can be like that for months and I can get beligerent and it is hard for me to see it. I don't know what your situation is with hormones, but I take estrogen and sometimes certain medicines increase the amount of estrogen you get if you are taking it, and you can have mood problems. I think that my thyroid problem (hashimotos) has caused my problem taking prednisone and I think there is someone else here too who can't take pred that also has hashis. I have other endo problems as well. I hate getting pred, though I love the first day or two. The last time I got it I was hearing voices and talking gibberish to myself and was really out there, he gave me two enormous shots and I was out of it for two months of sheer misery, crying, mad, sad, depressed, angry, frightened bigtime but kept telling myself it was just the pred and when I was about to check in to the hospital, it wore off. I 've been better the month or two following it wearing off though my arthritis and neck pain got much worse for some reason. I don't think he will give me pred again, or at least not that much.
Please write back and I hope you feel better. I don't want to scare you but I really think you need to call the doc that put you on lyrica, or any doc you think would best handle this, unless you know it is from the pred. Its just the typical precaution that is in the package insert for lyrica and you need to let your doc know, it may be a sign that you are developing a problem with it.
((((hugs)))) and I hope you feel better soon. It's probably either hormones or possible antidepressant/medication reaction. You might just check your meds in the pill book or online to see if these side effects are mentioned. I know about lyrica, but not the rest. Mood swings are normal sometimes, but if your husband thinks this is odd for you and you are having trouble realizing it but do feel he is right, then it sounds like something of concern.
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments