Secondary Lupus???

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Veteran Member

Date Joined Aug 2007
Total Posts : 4415
   Posted 8/27/2007 6:23 PM (GMT -6)   
I'm new.  My ANA is 1:320, but none of the antibodies show up (such as SSA, DS-DNA, etc.) and my doctor says it is probably due to the inflammation in my gut causing a secondary lupus-like syndrome.  Is this possible?  Can a Lupus-like syndrome be caused by inflammation in a specific spot in the body (such as the small intestine)?
-Razzle (Allergies, Asthma, Sulfite Sensitivity, Gluten Sensitivity, ??Crohn's/something else, Arthritis, Osteoporosis, & who knows what else)

Regular Member

Date Joined Jul 2007
Total Posts : 261
   Posted 8/27/2007 11:21 PM (GMT -6)   
Hi, Razzle and welcome. I'm not a doc, but I have heard of many auto-immune diseases being both primary and secondary. I know that lupus can manifest itself anywhere it wants. When I was first diagnosed with lupus, the main part of me hurting was my left lung. I have organ involvement with mine. I'm sure your doc will be doing more testing to come up with something more definite. Unfortunately, lupus is a very difficult disease to diagnose, so you may have to be patient while they test. I just wanted to say welcome to this forum and feel free to ask questions while looking for the answers you need. There are more great people here much more experienced with this disease than I am, so I'm sure they'll be along soon. Take care.
Always looking for the silver lining, Sharen

SLE '06, Sjogren's '06, Traumatic Head Injury '94
Prednisone 10mg and tapering, Caltrate 1200mg, Multi-vitamin, Prevacid 30 mg, Actonel 35mg

Veteran Member

Date Joined Jul 2005
Total Posts : 5403
   Posted 8/28/2007 9:07 AM (GMT -6)   
Hi Razzle and welcome. I'm not sure about lupus being secondary. I do know there is sometimes something called drug induced lupus caused by some meds. Lupus or lupus like syndromes can co-occur with other illnesses too. As I'm sure you have discovered, it can be really hard to sort out what might be causing your symptoms, especially since so many of these illnesses share so many of the the same symptoms. It can be so frustrating to know that something is wrong, but to not have any clear cut answers. From your signature it looks like you are having a lot of health problems. but docs are having a hard time coming up with a definite diagnosis.

I'm sorry you are going through this. Ask any other questions you have and we'll do our best to answer them. Hang in there and keep us posted on what you find out.

Take care
Diagnosis:  UCTD (lupus) 2006; Raynauds 2006; Sjogren's 2006; lupus symptoms began 2003; CFS 1991; Mono 1985
Meds:  Plaquenil 400mg; Prednisone 5-10mg; Tramadol 100mg 3-4x daily; Doxepin 25-50mg; Prevacid; Steriod Cream and Mouth Rinse for tongue and mouth ulcers; Hydrocodone 5/500 prn for severe pain; Artificial tears



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Veteran Member

Date Joined Dec 2006
Total Posts : 2818
   Posted 8/28/2007 9:49 AM (GMT -6)   
Hi Razzle, Lupus is such a weird disease anything is possible. I do know that there are people on here who have crohns and lupus though. I wouldn't let the doctor dismiss it so easily though. You need to have your blood checked again when you are not having so much inflmation going on. Even with full blown AI tests are not all that conclusive. But on the off chance that there is more to it than just lupus like symptoms you will want to be treated ASAP to hopfully control the disease as much as possible.
welcome to the group!
God Bless
Lupus, possible Crest, COPD, Cervical Cancer survivor. Osteoporosis
Prednisone 5mg, Plaquanil 800mg,Evista60mg, Effexor 150mg, HCTZ25/Triamterene37.5mg,Xanax x3
Only two defining forces have ever offered to die for you: 1. Jesus Christ 2. The American G. I

Veteran Member

Date Joined Dec 2005
Total Posts : 1950
   Posted 8/28/2007 11:35 AM (GMT -6)   
Hi Razzle,
I'm in the same boat with you. If you are overweight, carrying weight in the middle or top, have your insulin tested and your liver. You may have fatty liver from metabolic syndrome x (prediabetes-- also called diabetic liver), millions of Americans have this, whether you know it or not, and if you are overweight, you probably have it, though I had it when I was very skinny. It causes a raise in ANA and autoimmune problems and I think in the end they will find it is an autoimmune disease. It starts with insulin resistance caused by improper diet--to many carbs. Instead of burning sugar for energy, the liver stores it as fat and becomes enlarged. An abdominal ultrasound can show this. Eventually, the pancreas can't keep up with the huge demand for insulin and stops making insulin and you develop diabetes.

Right now, they believe fatty liver is caused by many things, but some scientists feel that those things only trigger the progression of the disease or may be symptoms rather than causes. The formal name is NAFLD (non-alcoholic fatty liver disease). I have sjogrens, which is related to NAFLD and some people with NAFLD do go on to develop ds-dna eventually and full-blown lupus. They used to not treat fatty liver or do anything about it, but now they are realizing it can be very serious and there are treatments available and diets for it and stuff you doc can do. If your doc believes that fatty liver is no big deal, they need to get updated.

I was labelled with secondary lupus because of the liver condition. I do not have dsdna, ssa or ssb, but biopsies of my salivary glands show chronic inflammatory cells of sjogrens, my schirmer test indicatesa AI disease, I have vitiligo, diabetes, hashimotos, osteoarthritis which are all ai diseases and have antibodies to my heart and my endocrine glands. I apparently did not inherit my AI disease, although I did inherit fatty liver.

Since you have gi problems, which I have also, it might make sense that they test you for something like that. I'm sure there are also other things that can cause lupus, but that is what I know about.

I'm glad you are here and look forward to hearing more from you! I hope you find an answer to your question!
Love, Marji
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments

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