Posted 9/21/2007 10:15 PM (GMT -6)
Just wanted to add that from my reading on the effects of cytokine and anticytokine therapies (I'm still trying to figure out what Dr. Frankenstein did to me by giving me interferon alpha, an immune booster, with an already elevated ANA and AI problems, I guess they just wanted to see what would happen!) anyway, from what I've read, interferons, which are chemicals in the infection fighting parts of your blood, when they are elevated constantly as they are with long infections, allergic reactions and exposure to toxins and stuff like that, will cause your body to make antibodies to different parts of your body, in lupus, to your ds-dna. Levels of anti-ds-dna can change if your body gets burned out from producing lots of it, or if you go into remission. I think these things are produced by organs like the liver and spleen and are in the white parts of your blood, rather than the red parts that are made in the bone marrow. Just like a person with liver disease will experience high levels of liver enzymes, after the liver becomes damaged enough, the enzymes drop, not because the person is well, but because the liver can't produce them right then. Same with diabetics and insulin. I think that a lot of docs don't take into consideration that labs can change like that based on your ability to produce the chemicals that cause an abnormal result. In other words, you need to be healthy enough to be sick in their eyes. I don't see why that can't happen with anti-ds-dna antibodies, since it happens with many other antibodies we create. Also, your medicines may be working, so you aren't making as much antibodies. There's always a chance for lab mistakes and such as well, so I would just try to get it repeated again until it comes out positive and be sure to get a copy of the old positive labs. Well, I hope that you get this sorted out and like the rest, I would trust your rheumy and yourself and your own feelings and knowledge of your body. Perhaps you are in a remission of sorts. Take care and let us know.
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments