Kristyn - I developed a positive anti-dsDNA titer at the 7 month mark in my Remicade treatment also. I felt like I had the worse case of flu in my life - joint pain everywhere and the extreme fatigue you describe. The good news is that it went away. Both my GI and rheumy felt that it was safe for me to continue on Remicade because the symptoms had begun to subside. I remained on Remicade for another 2.5 years. During that time my rheumy followed me closely to make sure I was not developing any organ involvement associated with lupus.
I have blood work drawn every four weeks and a U/A. I continued to have a positive anti-dsDNA titer but had no other symptoms. Approximately 56% of people getting Remicade develop this antibody from Remicade. Very few people ever develop lupus.
That said, you must decide the course you want to follow using the information provided by your doctors. My GI and rheumy are tops in their fields and I really trust them. I did do extensive research on the subject and felt from the research that they were acting in my best interest. I have to be on a biologic because of my joint disease. However, your situation and symptoms could be very different than mine. If you are not confident in what your doctors are telling you, by all means get a second opinion.
Also, should you want more info about
this anti-dsDNA situation with Remicade, I have lots of articles I could link for you if you like. I'm getting ready to go on vacation mid-week but will check this weekend and see if you have other questions.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?