plaquenil dosage question

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Regular Member

Date Joined Jan 2007
Total Posts : 146
   Posted 11/14/2007 9:59 AM (GMT -6)   
Good Day Everyone,
So here is my funny story of the day. I have been taking plaq for almost 6 months ( minus the two weeks when I got my wisdom teeth out and didn't take it).  When going to renew my perscription yesterday my pharmacist asks how come I hardly renew my perscription there was I getting it somewhere else? I said no I only just ran out so then I come for a new one. He tells me that is impossible as I am only renewing every 60 days and should be every 30 days.  Well I read every piece of information on this drug TWICE but I didn't bother to read my own dosage! I have been taking one a day 200 mg and should have been taking 2 a day 400 mg. So here is my question I am 190lbs and taking one I feel pretty darn good except still have rampant mouth sores. If I know take the appopriate dose will that mean I feel even better? Has anyone ever changed there dose ie: increased and felt a lot better I am hoping once I am on the correct doseage my mouth sores will be gone..
Thanks kindly
UCTD Plaquenil 400 mg and  Diclofenac 150 mg on really bad days Tylenol Arthritis.  and omega 3 with Moducare supplements

Veteran Member

Date Joined Jan 2005
Total Posts : 8616
   Posted 11/14/2007 10:59 AM (GMT -6)   
Hi Angela,

There a few different ways to start and maintain this med. Some doctors start you on 200mg/day and increase to 400 mg after a 1-4 weeks, to allow your body to adjust, then you stay on the 400 mg until you are feeling really well and then some docs lower the dose to 200 mg. Other docs start you on the 400 and lower or increase it as needed.

The fact that you are feeling better may mean the med is working . . . or it may mean that your flare has ended. I would ask YOUR doc what he/she would suggest. . . always good to get the big ok from the doc who prescribed.


In His Grip

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UCTD, Hashimotos, Inflammatory Bowel, Inflammatory Arthritis

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Veteran Member

Date Joined Dec 2006
Total Posts : 2818
   Posted 11/15/2007 12:39 AM (GMT -6)   
Hi Angela, I agree with Rosie, Best to ask your doctor what to do. I can tell you that my PCP put me on 800mg. My first rheumy took me off and said to take 400mg. than i went back to my PCP a month later and she put me back at 800mg. I didn't have any effect other than I felt better on 800 than on 400.
good luck
God Bless
Lupus like symptoms, with pbc symptoms,but of course that is subject to change in a moments notice! End Stage COPD w/CHF, Cervical Cancer survivor.  Osteoporosis,osteoarthritis
Prednisone,Plaquanil800mg,vicodin 3x5mg,Evista60mg, Effexor 150mg, HCTZ25/Triamterene37.5mg,Xanax x3 
Only two defining forces have ever offered to die for you: 1. Jesus Christ 2. The American G. I

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 11/15/2007 1:28 AM (GMT -6)   
I take 400mg a day. When I was short on meds I took 200mg a day for a while but when I got back up to 400 a day I felt oh so much better. I know you feel okay on 200 a day but your doctor wrote for 400 for a reason. Besides which mouth sores indicate that your disease is not fully under control. Perhaps the sores wouldn't happen as often or even stop if you were taking the full 400. Besides which getting control means slowing the progression- maybe even getting a remission. Please follow the doctor's instructions for your medication. I know we all hate pills, but none of us want this to kill us- but some people will die from lupus or complications caused by the disease we all love to hate. This is your future you are endangering by not taking a full dose.
Dx:fibromyalgia 2002, systematic lupus 2005, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sjögren's, pregnant due May 2008
Tx: plaquenil, Enbrel, Celebrex, Darvocet, Singulair, Flexeril, Baby Asprin,Prednisone

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