I'm in week 4 of a 6 week course of Mepron/Zith. Weeks 1 and 2 were low-level herx, week 3 was tough! So far, week 4 is very benign.
I see Dr. P in Wilton, CT, and so far he's had me do 5 weeks tetracycline, 1 week off, and now this. Then another week off, and I'm not sure what. Perhaps back on tetracycline, but at higher dose.
The mepron makes me a bit shakey, but I like it better than the tetracycline. During the tet cycle I felt like I had a stone in my gut the whole time. Plus, I herxed the whole five weeks.
A bit of background:
I had a bulls eye Jul 2007, and wasted precious time when an IDSA doc said, after a short course of abx, I had post-lyme, and I needed to "just wait 3-18 months". He went so far as to say the LLMDs were all quacks, and to avoid them. Of course I never got any better, and by this Spring he said I was a head-case and needed a psychiatrist. Familiar sad story, right?
My LLMD thinks I probably have had lyme for several years, as I've had constant tick exposure (hiked the Appalachian Trail in 2005, sleeping out 120+ nights - yes, I used to be able to DO things) and some known, apparently non-reactive, tick bites. Also, twice in 2006 I was on 3 weeks doxy for "possible lyme", and I got better and thought nothing of it. This may explain why as of Aug 2007 it was acting like late stage chronic lyme with heavy neuro symptoms, even though I "just got bit" in July.
I'm very happy to be seeing Dr. P now. I expect it'll take a while, but I'm already showing some improvement.
As a way to get my mental skills back, I write about this in my blog: http://lymechronicles.blogspot.com