Myself, major alcohol intolerance. Muscles and limbs ache as soon as alcohol goes in.
On the plus side, a few light drinks gets me tipsy fast, hence its cheap. Haha. One or two drinks per year max is what I seem to have had.
On a serious side, our body, liver, and immune system is already under strain. I couldn't think of anything worse than adding to it with things like drinking, smoking, drugs, or other unhealthy things.
Newly registered contributer/member, but long time lurker/reader.