Question for Phsinvent regarding Niacin?

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KO-LD
Veteran Member


Date Joined Aug 2007
Total Posts : 887
   Posted 11/17/2008 1:37 PM (GMT -7)   
Phsinvent, I don't know if you have seen the posting regarding Niacin for LD, but I was wondering what your opinion was on the subject?  I haven't been able to find much info on the subject.
Thanks, KO
2001 symptoms started:
Tingling in fingers and toes both sides, not tested at that time for LD
2007 Summer tested pos. WB, diagnosed with LD, tested neg for co-infections thru Igenex
Abx - Doxy 100mg 2x/day for 3 weeks (before diagnosis)
Amoxicillin 1gm 2x/day for 1 month
Amoxicillin 1gm 3x/day with Probenecid 500mg 2x/day  5 months 
Currently on Dr. Zhang's protocol 


Sulma
Regular Member


Date Joined Apr 2008
Total Posts : 366
   Posted 11/17/2008 1:46 PM (GMT -7)   

KO, I found this on another site.  The writer wrote a long entry about his LD journey.  He also categorized both the prescription and nutraceutical remedies he tried on their degree of effectiveness.  (not sure if the TOA here allows me to link it)

 

Here's a cut and paste of the list that made up his "very beneficial" category:

IV Rocephin
IV Zithromax
Rife Machine - EMEM 5
Cat's Claw (standardized to a minimum of 0.5%)
Pentacyclic Oxindole Alkaloids (POAs) - free of
Tetracyclic Oxindole Alkaloids (TOAs)
Artemisinin
RAW garlic 4-8 cloves/day Combined with Niacin 1,500/2,000 mg/day in divided doses


Sulma
Regular Member


Date Joined Apr 2008
Total Posts : 366
   Posted 11/17/2008 6:12 PM (GMT -7)   
I've been searching this evening for more Niacin/Neuroborreliosis information and found a few things.

Klinghardt's Niacin recommendation is based on research by Canadian physician Abraham Hoffer, who asserted as early as the 1950's that Vitamin B-3 has profound efficacy on Schizophrenia. The original "Hoffer Protocol" called for conventional (flush) Niacin at 1000mg 3x daily. It appears that Klinghardt speculated that Niacin might work on Neuroborreliosis based on Hoffer's research.

Here's one of the Hoffer papers. http://www.iahf.com/orthomolecular/reply_to_apa_tfr_7.pdf

Not surprisingly there is exactly zero entries on Medline for research done on Niacin as a treatment for Neuroborreliosis. Research is expensive and if there is no potential income to be earned from a patentable drug, there often are no studies done.

Sulma
Regular Member


Date Joined Apr 2008
Total Posts : 366
   Posted 11/20/2008 11:21 PM (GMT -7)   
Here's a study I found on Pubmed that found antibiotic efficacy of a combo of aspirin and Niacin against E. Coli.

Durham Science Center, Laboratory of Pharmaceutical Studies, Department of Chemistry, University of Nebraska, Omaha, Nebraska 68182, USA. bartzatt@mail.unomaha.edu

Two dipeptide drugs are synthesized utilizing an acetylsalicylic acid (aspirin) or nicotinic acid (niacin) molecule for the framework. A D-alanine-D-alanine dipeptide moiety is attached to the carbonyl carbon of acetylsalicylic acid (I) and nicotinic acid (II). Dipeptide derivatives (I) and (II) showed significant reduction of Escherichia coli (E. coli) bacterial growth and colony-forming units. A mixture of (I) and (II) induced growth inhibition of 8%, 17.5%, 28%, and 42.5% at concentrations of 100, 200, 300, and 400 microg/mL, respectively. Ampicillin demonstrated much less growth inhibition of this penicillin-resistant E. coli bacteria. Derivatives (I) and (II) showed significant reduction of colony-forming units at concentrations higher than 200 microg/mL, whereas ampicillin showed no significant affect on colony-forming units. Both (I) and (II) produced no violations of the Rule of 5, indicating favorable characteristics for bioavailability. Molecular properties were determined and showed (I) to have a Log Kow of -0.22 with aqueous solubility of 683.8 mg/L, whereas (II) had a Log Kow of -1.00 and aqueous solubility of 6859 mg/L. A mixture of the parent compounds acetyl salicylic acid and nicotinic acid demonstrated some antibacterial activity.

phsinvent
Veteran Member


Date Joined Aug 2006
Total Posts : 1155
   Posted 11/21/2008 11:59 AM (GMT -7)   
Sorry i don't know much about niacin and lyme.

Dowa
Veteran Member


Date Joined Sep 2008
Total Posts : 1120
   Posted 11/21/2008 12:24 PM (GMT -7)   
I bought some at Whole Foods and thought I would give it a try, started slowly with 100Mg twice a day (for four days) and it knocked me on my butt!! Anyone else try it??

KO-LD
Veteran Member


Date Joined Aug 2007
Total Posts : 887
   Posted 11/21/2008 3:04 PM (GMT -7)   
Thanks Sulma for the info!
 
Dowa, I got up to 3000mg a day but had what felt like a herx but with stomach upset and nausea/pain.  Usually when I've herxed I've run a low grade fever, but this time I was low 97.4.  My symptoms were the same as Sulma's.
KO
2001 symptoms started:
Tingling in fingers and toes both sides, not tested at that time for LD
2007 Summer tested pos. WB, diagnosed with LD, tested neg for co-infections thru Igenex
Abx - Doxy 100mg 2x/day for 3 weeks (before diagnosis)
Amoxicillin 1gm 2x/day for 1 month
Amoxicillin 1gm 3x/day with Probenecid 500mg 2x/day  5 months 
Currently on Dr. Zhang's protocol 


Sulma
Regular Member


Date Joined Apr 2008
Total Posts : 366
   Posted 11/21/2008 10:56 PM (GMT -7)   
Here's a little tidbit I found in a study of the "nicotinic (niacin) transport system"

"These lines of evidence suggest that the transport system of lomefloxacin and ofloxacin in rat erythrocytes is common with that of a water-soluble vitamin, nicotinic acid, to which quinolones are structurally analogous."


Notice that last part....the quinolones antibiotic group are structurally analogous to Niacin. Many of us here have taken antibiotics belonging to this group for our Lyme. Levaquin is one that I know is in this group. Cipro is another.

Post Edited (Sulma) : 11/21/2008 11:00:25 PM (GMT-7)

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