High CD4:CD8 ratio does not by itself mean you have Lyme. Nor does a high CD4 (which is why your ratio is high). I have a high ratio, but both CD4 and CD8 are very low. I think Lyme whacks out the immune system in general, whether it causes things to be high or low probably depends on how long someone has had Lyme, which (if any) coinfections one has, genetic factors, etc. This would be a good topic to discuss with your Lyme doctor.
Chronic Lyme Disease, Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, Anemia, Lymphopenia, intermittant Pancytopenia, chronic malabsorption/malnutrition, etc.; G-J Tube; Currently TPN-dependent.
Meds: Zofran, Pulmicort, Vitamin B12 Shots, Heparin (to flush PICC line).