I'd seen some nationally recognized doctors when I lived in Chicago and they all basically told me the same thing about the Mayo clinic...it is a good place to go to see a lot of specialists all at the same time and have them discuss your diagnosis after workup, but that their quality of doctor or better could be found in almost every major city.
I have been told by some doctors (in the minority) that it is a huge waste of time both based on my previous workups that had already been completed and their past experience with other patients. I have also been told its the place I needed to go by two doctors...and these two doctors were the worst two I had seen over the last two years and where absolutely convinced from day one that I had a mental disorder.
In hindsight, I'm am 100% happy that I did not go to the Mayo clinic. As stated above, do you really need to spend $20,000 to be treated in a condescending fashion? You can get that locally. Save you energy and money to battle Lyme and coinfections.
Just my opinion. Good luck!