Well first I have to tell you I am not a doctor so take my advice with a grain of salt. But with that said, I know of a lady whose doctor had her take 250mg a day of biaxin and 200mg of diflucan. The only thing about this is you really don't know the potency of the drug in your blood stream and the usual dose of biaxin is 1000mg a day. So he was really low dosing her if you ask me. Anyway, it's something to ask your doctor about I guess. Tho diflucan is for systemic yeast, I will tell you I think diflucan is a powerful drug on lyme and maybe coinf. They say it penetrates spinal fluid, joints, and tissues very well. I took it full dose when I was really going down hill, and my spine burned 1hr later and I could literally feel tiny worm like things racing around in my chest like they were trying to run away from something. Weird, I know.