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norepinephrine sensitivity

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Posted 12/14/2008 7:00 PM (GMT -8)
wondering if anyone has this? norepinephrine is the sympathetic nervous system's "stress hormone."
i have extreme sensitivity to NE. if my NE gets too high, i have serious heart, breathing and blood pressure problems. thus, i cannot drink any caffeine (not even decaf), cannot exercise, cannot be stressed or excited...

i recently tried the drug effexor and i had the most severe reaction because it increases norepinephrine.

i am just wondering if anyone else has this?
Posted 12/14/2008 7:24 PM (GMT -8)
I don't know about sensitivity to NE, but I have had experience with Effexor. When you go off of Effexor, do it very slowly, do not stop all at once. I had severe reactions with Effexor... I took it daily around 8am and would cycle through it so quickly that I would "crash" around 5pm every day. I would wind up in a ball crying and sobbing.... and this was when everyone was saying "it's all in your head".... HUH? And when I went off of it... no one told me about the withdrawal... jeese, I LOST IT for about 3 days straight before one of my doctors said "it's the Effexor, take an Effexor". It took me a good month to "wean" myself off of it.
Posted 12/14/2008 8:13 PM (GMT -8)
hi jelaine-
i have heard horrible things about effexor withdrawal. i am not on it. i barely survived the first "intro" dose. i am kind of thankful i went through that because i would definitely not like to go through the withdrawal - i had no idea it was such a big problem until i started researching effexor after i took it. wish i had some warning!

has anyone else had a horrible reaction to snris?
Posted 12/15/2008 11:10 AM (GMT -8)
Gracie: Have you ever done the Genomic Detox Profile by Great Smokie Lab, it can tell you if you are unable to detox your norepenephrine. That may be  adding to your problem. You said you have a "sensitivity" to NE and it could be that your body cannot detox it properly. Its a great test to have done and explain alot.  D

Posted 12/15/2008 7:38 PM (GMT -8)
hi dowa, thanks for alerting me to the test. sounds really really interesting.
i have had my catecholamines tested, and my NE is always normal, even low-normal, which is shocking given my sensitivity to it. however, my test also showed that my normetanephrines are low, which are the metabolites of NE. so this could indicate that i am not metabolizing it.
my doctors don't know how to explain this test result, i can find nothing on the internet about it, and it seems to be a big piece of what is going on but no one can explain it.
has anyone had their normetanephrines tested? did they come back low? can lyme's affect the workings and values of neurotransmitters? like the enzymes that mobilize and metabolize them?
Posted 12/15/2008 10:19 PM (GMT -8)
My neuro-transmitters are not normal, cant say that is from the lyme for sure. I am low in epinephine, high in norepinephine and very low in seratonin. The genomix test is VERY interesting, it also lists all drugs that your body cannot detox and that is GREAT information to have with Lyme (and other conditions as well). D

Posted 12/16/2008 3:55 PM (GMT -8)
my noremethaneprine 24 hr urine was high I set up an appointment with a Dr that specializes in Adrenal issues, I didnt know why I cannot drink any caffeine, I just used to get this weird feeling, if you have any other info I would greatly appreciate it, my metaneprins were normal

Posted 12/16/2008 5:49 PM (GMT -8)
judy, high normetanephrine levels are used to diagnose a pheochromocytoma - have you and your doctor ruled that out??? it is a tumor on the adrenal gland that secretes its own norepinephrine.
i was originally diagnosed with an autonomic nervous system dysfunction (POTS), and i know that many sufferers had high Norepinephrine and normetanephrine levels. it seems pretty common in adrenal disorders that one might see high levels.
it is really unusual for one to see low levels.
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