I am looking for some others to tell me they've been here. It is so frustrating for me. I have been on biaxin for 2 months, plaquenil for 1month, and doxy (switched to mino about a week ago) for over 8 months. My spine has been burning for 2 days now and feels swollen. The center of my gut from mid chest to belly button is burning and I feel nauseated pretty much all this time. My husband says give the meds time to work and I am inclined to think it is die off but DOES IT REALLY take a month for the plaquenil to kick in? That's what I think is creating this flare. I wasn't feeling well after a week or two of the plaq. but this is off the charts. I even didn't take my morning meds because I can't stand what I think is die off. It's too much too fast.