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Seronegative Lyme

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Posted 1/19/2009 12:09 PM (GMT -8)

A small subset of patients infected with Borrelia burgdorferi (Bb) does not produce Bb specific antibody. Our research provides additional evidence of a genetic predisposition for seronegativity in some individuals with Lyme disease. Because human leukocyte antigen (HLA) class II, a heterodimeric glycoprotein, plays an essential role in the regulation of antibody production, we investigated the difference in HLA genes between seropositive and seronegative patients with Lyme disease (LD). Our results show that HLA-DR7 was associated with anti-Bb antibody production. Nine out of the 22 seropositive LD patients (40.9%) had HLA-DRB1*0701, *0703, *0704 (HLA-DR7); only 1 out of the 18 seronegative LD patients (5.6%) had HLA-DR7 (odds ratio (OR)=11.8, P=0.0126). HLA-DRB1*01021 and HLA-DRB1*0101, *0104, *0105 (HLA-DR1) contributed negatively to anti-Bb antibody production. Seven of 18 seronegative LD patients had HLA-DR1, only 1 of 22 seropositive LD patients had HLA-DR1 (38.9% vs. 4.5%, OR=13.4, P=0.0138). These results suggest that the presence and or lack of production of specific antibody to Bb infection may be associated with particular HLA specificities of the Class II.

 

http://www.ncbi.nlm.nih.gov/pubmed/11532615?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Posted 1/27/2009 5:06 AM (GMT -8)

Kitty, you have verrrry interesting posts.  Is the benicar to reduce the TGF beta 1 levels?  How's it working out for you?  Thank you very much for your time.

Posted 1/27/2009 5:56 AM (GMT -8)
Hi and thanks! I try to post scientific evidence. There are too many theories out there that have no research to prove them.
(Can you tell I am a scientist by occupation? lol)

Yes, The Benicar is to reduce inflammation and allow the antibiotic to penetrate better. My TGF b1 was 2x the upper limit of normal. C4a was also high.

I am doing well on it. My BP hasn't dropped very much and I am on 2x the usual dose used for high BP. (20 mg 2x/day)

I will have the TGF B1 and I think c4a measured again in February or March. He follows these markers at 3 month intervals.

I recently had a couple of "good" days. Not great, but a sense that there may well be light at the end of the tunnel. Dizziness is my main symptom and the doctor said it will take time to reduce the inflammation he feels is causing it. (He believes it is the inflammation that causes the symptoms).
Posted 1/27/2009 6:20 AM (GMT -8)
Hi Kitty9309,

I am one of the seronegative Lyme patients. The scary thing is I had every clasic symptom of lyme, besides a positive Lyme titer. I had exposure to over 40 ticks in a four day period, including the nymphs, and adults. I had an engourged tick in my buttox, had the classic bulls eye rash, flu like symptoms and nearly every male symptom on the Lyme symptom list. It still took over 14 months to find a doctor to give me a clinical diagnosis. On my last test, nearly three years later I finally showed positive on ban 41, these have all been Quest lab tests. I am planing on having my first IngenX test when I visit my new LLMD's office in May.
Posted 1/27/2009 6:27 AM (GMT -8)
I know how you feel!

My doctor said to keep in mond that I had the most positive test of all- the bulls eye rash 14 years ago.

My IgeneX showed only 41 as positive. My doctor said that after many months of antibiotics, most patients will become positive on the WB.

It is frustrating, but things will start changing with patients becoming advocates.

Good luck at your upcoming appointment and hang in there.

~Kitty
Posted 1/27/2009 6:59 AM (GMT -8)
Thanks Katty, I agree 100% with you, I have become an advocate and will continue to be untill my last breath!!

Take care

Brandon
Posted 1/27/2009 7:01 AM (GMT -8)
Kitty, thanks so much for sharing. I hope you get to the light asap! You are very lucky that after 14 years you don't have alot of neuro issues.

My TGF is 5x above the normal top end, but I'm hesitant to do the antihypertensives because of low blood pressure. Thought dizziness was a possible side effect of Benicar. My C4a is also high, but has fluctuated greatly. I am new to this forum, but is there anyway you can send me a private message regarding your md? I am very interested in seeing him since he knows about these issues.
Posted 1/27/2009 7:12 AM (GMT -8)
I do have other neuro issues, but the dizziness is the everyday disrupter! I have had brief paralysis, numbness, muscle fasiculations everyday and everywhere, headaches, head pressure, mild hearing loss at the beginning 14 years ago.

I forgot to tell you my TGF level. It is 2x the upper limit of normal- about 28,000. Yours is 5x!!

What are you main symptoms and how long have you been ill?

Is you doctor an LLMD? What does he/she say about these tests?

Where are you located? We can't pm here w/o posting our e-mails in our profile. If you post yours, I will contact you.

My doctor only put me on Benicar after taking my BP and deciding because it was high in the office (always has been since getting ill) and is normal at home, by body would compensate. I wasn't so sure, but it did. I have symptoms of a Dysautonomia called POTS, due to high heart rate when standing- not officially diagnosed, but started with getting what we now know is Lyme.

I have learned so much from this doctor already in just 3 visits, I have hope for the first time! Joining PubMed was good for me. You get to the science better than just a general search, but the articles can be tough to read. I have to re-learn my Immunology from college 20 years ago!

Mino still has the ability to cross the Blood Brain Barrier on it's own.
Posted 1/27/2009 9:29 AM (GMT -8)
Kitty, you can reach me at vibranthealth123@gmail.com. That would be wonderful and we can chat further. Looking forward to it!
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