Here are my thoughts on the knee pain thing: Approximately 6 months ago or so, I "blew my knee out". Now, having been sick for 20 years now, at the age of 50 I walk and act like I am 90 most of the time so I know I did nothing to make this happen. I had been having a badly swollen knee for some time before this happened, but didn't know why. I went to an orthopedic doctor and could hardly get to and into his office, the pain was so severe. I had an MRI done and it showed torn cartilidge, torn meniscus, a cyst in my knee cap, and several other things that were "severe". He wanted to do surgery but I opted to not do that at the time and I am glad I didn't. I was afraid of infections, because I knew my immune system was on overload but I didn't know why. Months later I found out that I have late stage chronic lyme and I have had this for 20+ years and didn't know it. I researched the relation between the lyme and the knee thing, and I found that the knee "blowout" is a very telling symptom of Lyme disease and the fact that it has been in an active state for a long time. The Infectious disease doctor said my knee convinced him more that I have Lyme than my bloodwork did, which shows a lot of strong positives. So, I would say, yes, your knee problems are due to Lyme and/or co-infections, because I have those too. Hope this helps.