I was also initially confused about
the TGF B1 levels.
I found this on cytok dot com.
"Increased production and activation of latent TGF-beta have been linked to immune defects associated with malignancy and autoimmune disorders, to susceptibility to opportunistic infection, and to the fibrotic complications associated with chronic inflammatory conditions"
It also tracks with C4a. A recent article notes that C4a and C3a are initially high in acuce Lyme, but that C4a remains high in chronic Lyme.
Also found this that says TGF ba1 is a "double edge sword":
It wont let me cut and paste.
Here is the C4a article:
"C4a appears to be a valuable immunologic marker in patients with persistent symptoms of Lyme disease. "
I plan on asking my doctor more on these markers in a couple of weeks. He does not call himself an LLMD. His speciality is Rheumatology and Inflammatory Vascular Disease Specialist. Came from Yale (believe it or not!) and did research at NIH. I really like him. He looks at all angles. I have insomnia- we are checking adrenals. Have hypothyroid- we are trying to optimize my meds.
Hope the above articles help. I had some PubMed ones saved, but they didn't come across on my favorites.:((
14 years undiagnosed Lyme. I had a bulls-eye rash following a camping trip to NC in 1994. Swollen knees and replapsing and remitting vertigo followed for the next 14 years. All Lyme tests negative. Could possibly be B. lonestari due to being bit in the South.
Just began treatment with low dose Minocycline and Benicar.