Hi RMV. How long has your wife been on Mepron and Zithromax? What doses of each is she taking? This combo is used to treat the co-infection Babesiosis, although Zithromax can be effective against Lyme also.
How many doses of Ceftin has she taken? Does she take 500 mg twice daily? Ceftin is used to treat Lyme. It is not unusual for symptoms to flare when a new medication is added. Does your wife keep a symptom journal? This is very important. One way to do this is to document the main symptoms she has each day with a numerical rating of their severity from 1-10. Over time when she reviews this, she can see when her herxes occur and how she is responding to the meds.