Lyme can cause psychiatric problems, such as depression and anxiety. Just being so sick for so long can also cause depression. As the saying goes, we get sick and tired of being sick and tired. It can wear you down after a while. Whether you seek treatment for the depression is up to you. The downside is that doctors can be too quick to treat depression with medications. This is in part because insurance companies push medications because they are often cheaper than long-term therapy. If the depression is being caused by the Lyme itself, then only treating the underlying infection will ultimately get rid of the depression. If the depression is being caused by the psychological burden of the disease, then joining a support group or seeking psychological treatment may help. Medications may also help, but you should discuss them with your LLMD to cover the possible side effects of taking these.