I did the shots 3X weekly at 1,200,000. I know some people do twice that amount but I think that would be too much to inject at least for me it would have been. Dr. H also said that he has patients that have been doing the injections for over a year. I hadn't seen any improvement in 3 months and he said that would have been long enough to notice. So I quit after 3 months. From everything the doc said and what I have read you should be doing at least 2 a week to keep the levels up.