My daughter was on a similar combo for Babesia: Zithromax, Plaquenil, Mepron, and her doctor also had her taking an herb called Artemisinin 200 mg 2x/day. She did well on this combo, however, we came off of it after three months because we added a lyme neuro to our list of doctors and he felt that she had enough of those meds and should be okay. We didn't have her retested yet. He started treating her for Bartonella, but she became super sensitive to the meds and now can no longer take pill form of anything. So we are starting IV Rocephin to take care of lyme first, then we will attack Bartonella. This is getting us no where fast, be we have to obey how her body is responding to all of this, too.
You should do well and I have read that adding Artemisinin helps a great deal with the treatment regimen. You can probably search out some of the threads written about it. The only problem I will let you know about is that she was having panic attacks with hallucinations. Our lyme neuro told us that those come from the anti-malarial meds. Since she has been off of them they have stopped. I'm not saying you will experience this, but in case you do, rest assured it is from these meds.